Ethanol, 2-(trimethylsilyl)-, carbamate

Base Information

• Chemical Name: Ethanol, 2-(trimethylsilyl)-, carbamate
• CAS No.: 3124-37-6
• Molecular Formula: C6H15 N O2 Si
• Molecular Weight: 161.276
• NSC Number: 96790
• DSSTox Substance ID: DTXSID20185161
• Nikkaji Number: J61.503J
• Wikidata: Q83056144
• Mol file: 3124-37-6.mol

Synonyms:3124-37-6;Carbamic acid, 2-(trimethylsilyl)ethyl ester;2-(Trimethylsilyl)ethanol carbamate;ETHANOL, 2-(TRIMETHYLSILYL)-, CARBAMATE;BRN 2410549;2-(Trimethylsilyl)ethyl ester of carbamic acid;2-(trimethylsilyl)ethyl carbamate;C6H15NO2Si;NCIOpen2_001609;SCHEMBL78042;C6-H15-N-O2-Si;2-(trimethylsilyl)ethylcarbamate;beta-trimethylsilylethyl carbamate;DTXSID20185161;QWYTUBPAXJYCTH-UHFFFAOYSA-N;NSC96790;NSC 96790;NSC-96790;2-trimethylsilylethyloxycarbonyl amine;LS-67095;Carbamic acid 2-(trimethylsilyl)ethyl ester;carbamic acid 2-trimethylsilanyl-ethyl ester;CS-0380508

Chemical Property of Ethanol, 2-(trimethylsilyl)-, carbamate

Chemical Property:

• Vapor Pressure: 0.0579mmHg at 25°C
• Boiling Point: 232.8°Cat760mmHg
• Flash Point: 94.6°C
• Density: 0.946g/cm³
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 161.087205256
• Heavy Atom Count: 10
• Complexity: 119

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)CCOC(=O)N

Technology Process of Ethanol, 2-(trimethylsilyl)-, carbamate

There total 5 articles about Ethanol, 2-(trimethylsilyl)-, carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + 1,1'-carbonyldiimidazole (530-62-1) → carbamic acid 2-trimethylsilylethyl ester (3124-37-6)

Guidance literature:

2-(Trimethylsilyl)ethanol; 1,1'-carbonyldiimidazole; In toluene; at 20 ℃; for 5h;

With ammonium hydroxide; In water monomer; toluene;

Reference yield: 81.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + urea (57-13-6) → carbamic acid 2-trimethylsilylethyl ester (3124-37-6)

Guidance literature:

With iron(II) bromide; In 1,4-dioxane; at 150 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/cssc.201600587

Reference yield: 72.7%

2-(Trimethylsilyl)ethanol (2916-68-9) + sodium isocyanate (917-61-3) → carbamic acid 2-trimethylsilylethyl ester (3124-37-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 19 - 23 ℃; Inert atmosphere;

upstream raw materials:

2-(Trimethylsilyl)ethanol

sodium isocyanate

phenyl chloroformate

1,1'-carbonyldiimidazole

Refernces

• 1、 -. "BORON-CONTAINING RHO KINASE INHIBITORS". Paragraph 00307. . Retrieved 2021/02/12.
• 2、 Gwon, Donghyeon,Hwang, Heejun,Kim, Hye Kyung,Marder, Seth R.,Chang, Sukbok. "Synthesis of 8-Aminoquinolines by Using Carbamate Reagents: Facile Installation and Deprotection of Practical Amidating Groups". supporting information. p. 17200 - 17204. Retrieved 2016/01/25.