3-Furanmethanol

Base Information

• Chemical Name: 3-Furanmethanol
• CAS No.: 4412-91-3
• Molecular Formula: C5H6O2
• Molecular Weight: 98.1014
• Hs Code.: 29321900
• European Community (EC) Number: 224-570-7
• UNII: 6E4MK4DV6C
• DSSTox Substance ID: DTXSID70196045
• Nikkaji Number: J205.791C
• Wikidata: Q72479668
• Metabolomics Workbench ID: 134055
• ChEMBL ID: CHEMBL440914
• Mol file: 4412-91-3.mol

Synonyms:3-FURANMETHANOL;4412-91-3;Furan-3-methanol;furan-3-ylmethanol;3-Furylmethanol;3-(Hydroxymethyl)furan;3-HYDROXYMETHYLFURAN;3-Furfuryl alcohol;Furan-3-yl-methanol;3-Furancarbinol;3-Furylcarbinol;furano-3-metanol;furanne-3-methanol;(furan-3-yl)methanol;MFCD00005352;6E4MK4DV6C;EINECS 224-570-7;3-(hydroxymethyl)-furan;3-furan methanol;3-furanylmethanol;3-Furyl Alcohol;(3-furyl)carbinol;3-Furylmethanol #;furanne-3-m?thanol;Furan-3-methanol, 99%;UNII-6E4MK4DV6C;CHEMBL440914;DTXSID70196045;STR02020;GEO-01444;AKOS005174964;AM85772;CS-W007708;HY-W007708;SB61307;BP-10475;SY033055;F0360;FT-0615763;FT-0668903;EN300-50082;1,4-Androstadien-3,17-dione17-ethyleneketal;A826496;AE-641/00180028;J-640069;W-200375;Z397587426

Chemical Property of 3-Furanmethanol

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 0.588mmHg at 25°C
• Refractive Index: n20/D 1.484(lit.)
• Boiling Point: 180.3 °C at 760 mmHg
• PKA: 14.49±0.10(Predicted)
• Flash Point: 38.3 °C
• PSA: 33.37000
• Density: 1.14 g/cm³
• LogP: 0.77190
• Storage Temp.: Flammables area
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 98.036779430
• Heavy Atom Count: 7
• Complexity: 54

Purity/Quality:

99% ^*data from raw suppliers

3-Furanmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, Xi
• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=COC=C1CO
• Uses: 3-Furanmethanol can be used in methods to support gastrointestinal homeostasis.

Technology Process of 3-Furanmethanol

There total 30 articles about 3-Furanmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-furancarboxylate (614-98-2) → furan-3-methanol (4412-91-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1246/bcsj.56.2661

Reference yield: 99.0%

furan-3-carboxaldehyde (498-60-2) → furan-3-methanol (4412-91-3)

Guidance literature:

With sodium tetrahydroborate; water; In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1002/asia.201403190

Reference yield: 96.0%

furan-3-ylmethyl acetate (30614-67-6) → furan-3-methanol (4412-91-3)

Guidance literature:

With zirconocene dichloride; diisobutylaluminium hydride; In tetrahydrofuran; at -20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03947

upstream raw materials:

3-Furoic acid

ethyl 3-furancarboxylate

4-phenyl-1,3-oxazole

propargyl alcohol

Downstream raw materials:

3-(chloromethyl)furan

5-hydroxymethyl-6,6-diphenyl-2,7-dioxabicyclo<3.2.0>-Δ³-heptene

3-furylmethyl 1-phenyl-1H-tetrazol-5-yl sulfide

pleraplysillin-2

Refernces

• 1、 Shanmugham, M. Sundaram,White, James D.. "A new route to furanoeremophilane sesquiterpenoids. Synthesis of (±)-6β-hydroxyeuryopsin". . p. 44 - 45. Retrieved 2004.
• 2、 Czeskis, B. A.,Baeckstroem, P.,Moiseenkov, A. M.,Norin, T.. "NEW SYNTHESIS OF PERILLENE AND SOME OTHER FURANOTERPENES BY CYCLOPROPYLCARBINYL REARRANGEMENT". . p. 131 - 134. Retrieved 1989.
• 3、 Yuhas, Shelby C.,Laverty, Daniel J.,Lee, Huijin,Majumdar, Ananya,Greenberg, Marc M.. "Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor". supporting information. p. 8099 - 8107. Retrieved 2021/06/21.
• 4、 Sharifi, Sina,Sharifi, Hannah,Koza, Darrell,Aminkhani, Ali. "Disproportionation of aliphatic and aromatic aldehydes through Cannizzaro, Tishchenko, and Meerwein–Ponndorf–Verley reactions". . p. 803 - 808. Retrieved 2021/07/20.