Cgp 71683 hydrochloride

Base Information

• Chemical Name: Cgp 71683 hydrochloride
• CAS No.: 192322-50-2
• Molecular Formula: C26H30ClN5O2S
• Molecular Weight: 512.0667
• UNII: 45B73P82A3
• Wikidata: Q27258822
• ChEMBL ID: CHEMBL582005
• Mol file: 192322-50-2.mol

Synonyms:CGP 71683 A;CGP-71683A;CGP71683A

Chemical Property of Cgp 71683 hydrochloride

Chemical Property:

• Vapor Pressure: 1.19E-22mmHg at 25°C
• Boiling Point: 747.2°Cat760mmHg
• Flash Point: 405.7°C
• Density: g/cm³
• Storage Temp.: Desiccate at +4°C
• Solubility.: H2O: ~14 mg/mL, soluble
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 511.1808741
• Heavy Atom Count: 35
• Complexity: 751

Purity/Quality:

98%Min ^*data from raw suppliers

CGP 71683 hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1CNC2=NC3=CC=CC=C3C(=N2)N)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54.Cl
• Description: CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.