4-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL

Base Information

• Chemical Name: 4-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL
• CAS No.: 3199-71-1
• Molecular Formula: C9H9ClO
• Molecular Weight: 168.623
• Hs Code.: 2906299090
• Mol file: 3199-71-1.mol

Synonyms:4-chloro-1-indanol;4-chloroindan-1-ol;1H-Inden-1-ol,4-chloro-2,3-dihydro;4-Chlor-indan-1-ol;4-Chlor-1-indanol;

Chemical Property of 4-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL

Chemical Property:

• Vapor Pressure: 0.00117mmHg at 25°C
• Boiling Point: 287.3oC at 760 mmHg
• Flash Point: 127.5oC
• PSA: 20.23000
• Density: 1.322g/cm3
• LogP: 2.31960

Purity/Quality:

98% ^*data from raw suppliers

4-Chloro-2,3-dihydro-1H-inden-1-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL

There total 7 articles about 4-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-chloro-2,3-dihydro-1H-inden-1-one (15115-59-0) → 4-chloro-2,3-dihydro-1H-inden-1-ol (3199-71-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1021/jm061475p

Reference yield:

inden-1-one (83-33-0) → 4-chloro-2,3-dihydro-1H-inden-1-ol (3199-71-1)

Guidance literature:

With hydrogenchloride; sodium borohydrid; In ethanol;

Reference yield:

(E)-ethyl 2-chlorocinnamate (24393-51-9) → 4-chloro-2,3-dihydro-1H-inden-1-ol (3199-71-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h

2: 94 percent / KOH / ethanol; H₂O / 4 h / Ambient temperature

3: 1.) SOCl₂, 2.) AlCl₃ / 1.) reflux, 12 h; 2.) CH₂Cl₂, RT, 4 h

4: NaBH₄ / methanol / 2 h

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; hydrogen; palladium on activated charcoal; In methanol; ethanol; water; ethyl acetate;

DOI:10.1016/S0040-4020(01)91335-3

upstream raw materials:

4-chloro-2,3-dihydro-1H-inden-1-one

3-(2-chlorophenyl)propanoic acid

(E)-ethyl 2-chlorocinnamate

ethyl 3-(2-chlorophenyl)propanoate

Downstream raw materials:

7-chloro-1H-indene

Refernces

• 1、 -. "CYCLIC COMPOUNDS". Paragraph 0643; 0644; 0645. . Retrieved 2016/11/24.
• 2、 -. "NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE". Page/Page column 59. . Retrieved 2012/09/10.