6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolinium

Base Information

• Chemical Name: 6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolinium
• CAS No.: 32749-01-2
• Molecular Formula: C12H16NO2
• Molecular Weight: 206.265
• DSSTox Substance ID: DTXSID201238608
• Nikkaji Number: J403.588G
• ChEMBL ID: CHEMBL1178693
• Mol file: 32749-01-2.mol

Synonyms:isoquinolinium, 3,4-dihydro-6,7-dimethoxy-2-methyl-;32749-01-2;3,4-Dihydro-6,7-dimethoxy-2-methylisoquinolinium;6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium;CHEMBL37607;6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium;SCHEMBL3699579;CHEMBL1178693;DTXSID201238608;BBL036796;BDBM50014649;STL553534;AKOS037503421;RTE3_000037;NCGC00246212-01;PK04_181312;2-Methyl-6,7-dimethoxy-3,4-dihydroisoquinolinium;6,7-Dimethoxy-2-methyl-3,4-dihydro-isoquinolinium;iodide

Chemical Property of 6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolinium

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 206.118103753
• Heavy Atom Count: 15
• Complexity: 252

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[N+]1=CC2=CC(=C(C=C2CC1)OC)OC

Technology Process of 6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolinium

There total 2 articles about 6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

armepavine (5884-67-3,3423-14-1) → 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (16620-96-5) + 3,4-dihydro-6,7-dimethoxy-2-methylisoquinolinium (32749-01-2) + (4-hydroxyphenyl)methanol (623-05-2)

Guidance literature:

With dihydrogen peroxide; In methanol; water; for 14h; Ambient temperature; ascorbate oxidase from Cucurbita pepo medullosa L_., phosphate buffer pH 7.0;

Reference yield:

9-deuterio-9-hydroxylaudanosine → 3,4-dihydro-6,7-dimethoxy-2-methylisoquinolinium (32749-01-2) + α-Deutero-3,4-dimethoxybenzaldehyd (27167-79-9)

Guidance literature:

With salcomine; oxygen; In methanol; Product distribution; Mechanism; Heating;

Reference yield: 73.0%

3,4-dihydro-6,7-dimethoxy-2-methylisoquinolinium (32749-01-2) + methylmagnesium bromide (75-16-1) → (+/-)-carnegine (490-53-9)

Guidance literature:

With Bromotrichloromethane; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/ejoc.201701320

upstream raw materials:

armepavine

Downstream raw materials:

(+/-)-carnegine

6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 Canonica, Luigi,Galliani, Guido,Nali, Micaela,Rindone, Bruno,Tollari, Stefano. "BIOMIMETIC OXIDATIONS OF BENZYLISOQUINOLINE ALKALOUDS. II. THE BIS(SALICYLALDEHYDE)ETHYLENEDIIMINECOBALT(II)-CATALYZED OXIDATION OF BENZYLISOQUINOLINES WITH OXYGEN". . p. 7 - 12. Retrieved 2007/10/02.