4-CHLORO-QUINAZOLINE

Base Information

• Chemical Name: 4-CHLORO-QUINAZOLINE
• CAS No.: 5190-68-1
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.594
• Hs Code.: 2933990090
• Mol file: 5190-68-1.mol

Synonyms:4-Chloroquinazoline;NSC 53480;4-chlorchinazolin;

Chemical Property of 4-CHLORO-QUINAZOLINE

Chemical Property:

• Vapor Pressure: 0.00624mmHg at 25°C
• Melting Point: 96-100 °C
• Refractive Index: 1.662
• Boiling Point: 281 °C at 760 mmHg
• PKA: 0.83±0.30(Predicted)
• Flash Point: 150.6 °C
• PSA: 25.78000
• Density: 1.349 g/cm³
• LogP: 2.28320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: MeOH

Purity/Quality:

99% ^*data from raw suppliers

4-Chloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: Xi,T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Chloroquinazoline can be used to prepare agricultural fungicides.

Technology Process of 4-CHLORO-QUINAZOLINE

There total 21 articles about 4-CHLORO-QUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(methylsulfanyl)quinazoline (13182-59-7) → 4-chloroquinazoline (5190-68-1)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; acetonitrile; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2010.06.056

Reference yield: 93.0%

4-quinazolinol (491-36-1,134434-33-6) → 4-chloroquinazoline (5190-68-1)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 0.333333h; Heating / reflux;

Reference yield: 92.7%

4-Hydroxyquinazoline (491-36-1) → 4-chloroquinazoline (5190-68-1)

Guidance literature:

With thionyl chloride; Reflux;

upstream raw materials:

4-Hydroxyquinazoline

4-quinazolinol

phosphorus pentachloride

trichlorophosphate

Downstream raw materials:

4-Hydroxyquinazoline

N-[2-(2-naphthyl)ethyl]-4-quinazolinamine

C₁₅H₁₀N₄O

4-(2-methoxycarbonylphenylamino)quinazoline

Refernces

• 1、 Alafeefy, Ahmed M.,Ahmad, Rehan,Abdulla, Maha,Eldehna, Wagdy M.,Al-Tamimi, Abdul-Malek S.,Abdel-Aziz, Hatem A.,Al-Obaid, Omar,Carta, Fabrizio,Al-Kahtani, Abdulla A.,Supuran, Claudiu T.. "Development of certain new 2-substituted-quinazolin-4-ylaminobenzenesulfonamide as potential antitumor agents". . p. 247 - 253. Retrieved 2016.
• 2、 -. "Preparation and application of substituted pyrazole compound containing pyriminostrobin". Paragraph 0445; 0449-0451. . Retrieved 2021/10/20.