Trimeperidine

Base Information

• Chemical Name: Trimeperidine
• CAS No.: 64-39-1
• Molecular Formula: C₁₇H₂₅NO₂
• Molecular Weight: 275.391
• European Community (EC) Number: 200-583-3
• DSSTox Substance ID: DTXSID90861607
• Nikkaji Number: J4.835F
• Wikipedia: Trimeperidine
• Wikidata: Q4463083
• NCI Thesaurus Code: C76848
• ChEMBL ID: CHEMBL2107685
• Mol file: 64-39-1.mol

Synonyms:Dimethylmeperidine;Isopromedol;Promedol;Trimeperidine

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Chemical Property of Trimeperidine

Chemical Property:

• Vapor Pressure: 5.12E-05mmHg at 25°C
• Melting Point: 182-183 °C
• Refractive Index: 1.5420 (estimate)
• Boiling Point: 348.2°C at 760 mmHg
• PKA: 7.83±0.10(Predicted)
• Flash Point: 109°C
• PSA: 29.54000
• Density: 1.04g/cm³
• LogP: 3.13310
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 275.188529040
• Heavy Atom Count: 20
• Complexity: 338

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OC1(CC(N(CC1C)C)C)C2=CC=CC=C2

Technology Process of Trimeperidine

There total 13 articles about Trimeperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ trimeperidine (64-39-1,29606-00-6,29606-10-8,32204-65-2)

Guidance literature:

1,2,5-Trimethyl-4-phenyl-piperid-4-ol (γ-Isomer), Propionylchlorid, (C2H5)3N;

DOI:10.1007/BF00780832

Reference yield:

1,2,5-Trimethyl-1-(2-methyl-acryloyloxymethyl)-4-phenyl-4-propionyloxy-piperidinium; chloride (91418-06-3) → 1,2,5-trimethyl-4-phenyl-4-propionoxypiperidine (64-39-1,29606-00-6,734484-45-8,744980-83-4,749793-19-9,785718-21-0,721875-25-8)

Guidance literature:

With water; at 37 ℃; Rate constant; pH 8.5;

DOI:10.1007/BF00758996

Reference yield:

→ 1,2,5-trimethyl-4-phenyl-4-propionoxypiperidine (64-39-1,29606-00-6,734484-45-8,744980-83-4,749793-19-9,785718-21-0,721875-25-8)

Guidance literature:

α-Form von 1.2.5-Trimethyl-4-phenyl-piperidol-(4), 1.) Propionylchlorid, Bzl. 2.) Kochen;

upstream raw materials:

propionyl chloride

(+/-)-1,2t,5c-trimethyl-4-phenyl-piperidin-4r-ol

propionic acid anhydride

1,2,5-trimethyl-4-piperidone

Refernces