1,3-Benzodioxole-5-methanol,α-(aminomethyl)-

Base Information

• Chemical Name: 1,3-Benzodioxole-5-methanol,α-(aminomethyl)-
• CAS No.: 7464-97-3
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Hs Code.: 2932999099
• Mol file: 7464-97-3.mol

Synonyms:Piperonylalcohol, α-(aminomethyl)- (7CI,8CI);1-(1,3-Benzodioxol-5-yl)-2-aminoethanol;NSC 400140;2-Amino-1-benzo[1,3]dioxol-5-yl-ethanol;2-Amino-1-(1,3-benzodioxol-5-yl)ethanol;

Chemical Property of 1,3-Benzodioxole-5-methanol,α-(aminomethyl)-

Chemical Property:

• Vapor Pressure: 2.89E-06mmHg at 25°C
• Refractive Index: 1.611
• Boiling Point: 374.3 °C at 760 mmHg
• Flash Point: 180.1 °C
• PSA: 64.71000
• Density: 1.338 g/cm³
• LogP: 1.10770

Purity/Quality:

99% ^*data from raw suppliers

1-(1,3-Benzodioxol-5-yl)-2-aminoethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-51
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Benzodioxole-5-methanol,α-(aminomethyl)-

There total 8 articles about 1,3-Benzodioxole-5-methanol,α-(aminomethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(benzo[d][1,3]dioxol-6-yl)-2-hydroxyacetonitrile (86215-81-8,33630-47-6) → 1-(3,4-methylenedioxyphenyl)-2-aminoethanol (7464-97-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; a) 0 deg C, 6 h, b) RT, overnight, c) reflux, 4 h;

Reference yield:

sodium benzo[d][1,3]dioxol-5-yl(hydroxy)methanesulfonate (37589-10-9) → 1-(3,4-methylenedioxyphenyl)-2-aminoethanol (7464-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / 0.25 h

2: 3.97 g / LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; water;

DOI:10.1248/cpb.37.870

Reference yield:

benzo[1,3]dioxol-5-yl-glyoxylonitrile (82461-58-3) → 1-(3,4-methylenedioxyphenyl)-2-aminoethanol (7464-97-3)

Guidance literature:

With palladium; acetic acid; Hydrogenation;

DOI:10.1002/ardp.19312693504

upstream raw materials:

2-(benzo[d][1,3]dioxol-6-yl)-2-hydroxyacetonitrile

benzo[1,3]dioxol-5-yl-glyoxylonitrile

1-benzo[1,3]dioxol-5-yl-2-nitro-ethanone

sodium benzo[d][1,3]dioxol-5-yl(hydroxy)methanesulfonate

Refernces

• 1、 Kihara,Ohnishi,Vangveravong,Kobayashi. "Syntheses of apogalanthamine analogues as α-adrenergic blocking agents. XII. Syntheses and stereochemistry of methoxy and methylenedioxy derivatives of 8-hydroxy-5,6,7,8-tetrahydrodibenz[c,e]azocines". . p. 870 - 876. Retrieved 2007/10/02.