16-hydroxyprogesterone

Base Information

• Chemical Name: 16-hydroxyprogesterone
• CAS No.: 14264-44-9
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.467
• Mol file: 14264-44-9.mol

Synonyms:16-Hydroxyprogesterone

Chemical Property of 16-hydroxyprogesterone

Chemical Property:

• Vapor Pressure: 1.51E-11mmHg at 25°C
• Boiling Point: 487.4°Cat760mmHg
• Flash Point: 262.7°C
• PSA: 54.37000
• Density: 1.15g/cm³
• LogP: 3.69430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16-hydroxyprogesterone

There total 2 articles about 16-hydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Progesterone (57-83-0) → 21-Hydroxyprogesterone (64-85-7) + Cortexolone (152-58-9) + 16β-hydroxyprogesterone (17779-71-4,438-07-3,2781-78-4,14264-44-9) + 2beta-Hydroxyprogesterone (604-29-5,604-28-4,123287-83-2)

Guidance literature:

With Bacillus megaterium cytochrome P₄₅₀ BM₃ monooxygenase (R₄₇Y/T₄₉F/V₇₈T/A₈₂F/F₇₈A)-expressing cells; at 25 ℃; for 24h; diastereoselective reaction;

DOI:10.1038/nchem.1113

Reference yield:

Progesterone (57-83-0) → 21-Hydroxyprogesterone (64-85-7) + 2β,16β-hydroxyprogesterone (1334177-12-6) + Cortexolone (152-58-9) + 16β-hydroxyprogesterone (17779-71-4,438-07-3,2781-78-4,14264-44-9) + 2beta-Hydroxyprogesterone (604-29-5,604-28-4,123287-83-2)

Guidance literature:

With Bacillus megaterium cytochrome P₄₅₀ BM₃ monooxygenase (V₇₈L/A₈₂F/F₈₇A)-expressing cells; at 25 ℃; for 24h; diastereoselective reaction;

DOI:10.1038/nchem.1113

upstream raw materials:

Progesterone

Refernces