2-Cyclohexene-1-acetyl chloride

Base Information

• Chemical Name: 2-Cyclohexene-1-acetyl chloride
• CAS No.: 3514-86-1
• Molecular Formula: C8H11ClO
• Molecular Weight: 158.628
• Mol file: 3514-86-1.mol

Synonyms:

Chemical Property of 2-Cyclohexene-1-acetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyclohexene-1-acetyl chloride

There total 5 articles about 2-Cyclohexene-1-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl cyclohex-2-enyl-acetate (55510-68-4,200637-78-1) → 2-(cyclohex-2-en-1-yl)acetyl chloride (3514-86-1)

Guidance literature:

ethyl cyclohex-2-enyl-acetate; With potassium hydroxide; In ethanol; water; for 5h; Heating;

With oxalyl dichloride; In benzene; at 0 ℃; for 1h;

DOI:10.1016/S0040-4020(98)01075-8

Reference yield:

2-(cyclohex-2-enyl)acetic acid (3675-31-8) → 2-(cyclohex-2-en-1-yl)acetyl chloride (3514-86-1)

Guidance literature:

With thionyl chloride; In benzene;

Reference yield:

diethyl 2-(cyclohex-2-enyl)malonate (6305-63-1) → 2-(cyclohex-2-en-1-yl)acetyl chloride (3514-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH, MeOH

2: 200 °C

3: SOCl₂ / benzene

With methanol; potassium hydroxide; thionyl chloride; In benzene;

upstream raw materials:

2-(cyclohex-2-enyl)acetic acid

ethyl cyclohex-2-enyl-acetate

ethyl (cyclohexen-3-yl)acetate

diethyl 2-(cyclohex-2-enyl)malonate

Downstream raw materials:

(+/-)-3--propionsaeure-methylester

1-(cyclohex-2-enyl)-3-phenyl-3-(toluene-4-sulfonyl)propan-2-one

1-methyloctahydro-2H-indol-2-one

2-(2-cyclohexenyl)acetamide

Refernces

• 1、 Davies, Jacob,Svejstrup, Thomas D.,Fernandez Reina, Daniel,Sheikh, Nadeem S.,Leonori, Daniele. "Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition-Metal-Free Hydroamination and N-Arylation Reactions". supporting information. p. 8092 - 8095. Retrieved 2016/07/16.
• 2、 Ghorai, Binay K.,Menon, Suneetha,Lee Johnson, Dennis,Herndon, James W.. "Inversion of the direction of stereoinduction in the coupling of chiral γ,δ-unsaturated fischer carbene complexes with o-ethynylbenzaldehyde". . p. 2121 - 2124. Retrieved 2007/10/03.