2-Propenoyl fluoride, 3-phenyl-

Base Information

• Chemical Name: 2-Propenoyl fluoride, 3-phenyl-
• CAS No.: 351-59-7
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.152
• Mol file: 351-59-7.mol

Synonyms:

Chemical Property of 2-Propenoyl fluoride, 3-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoyl fluoride, 3-phenyl-

There total 9 articles about 2-Propenoyl fluoride, 3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Cinnamic acid (621-82-9) → 3-phenylacryloyl fluoride (38986-89-9,351-59-7)

Guidance literature:

With sodium fluoride; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01377

Reference yield: 75.0%

(E)-3-phenylacrylic acid (140-10-3) → 3-phenylacryloyl fluoride (38986-89-9,351-59-7)

Guidance literature:

With potassium fluoride; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; N,N`-sulfuryldiimidazole; trifluoroacetic acid; In acetonitrile; at 40 ℃; for 1h; Sealed tube;

DOI:10.1021/acs.orglett.0c02566

Reference yield: 68.0%

cinnamoyl chloride (102-92-1,17082-09-6) → 3-phenylacryloyl fluoride (38986-89-9,351-59-7)

Guidance literature:

With potassium hydrogenfluoride; tetrabutyl-ammonium chloride; water; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1055/a-1649-5460

upstream raw materials:

Cinnamic acid

carbon monoxide

[(E)-2-bromoethenyl]benzene

1,3-dibromo-1,1-difluoro-3-phenylpropane

Downstream raw materials:

methyl cinnamate

N-benzylcinnamamide

(3,3,3-trifluoroprop-1-enyl)benzene

(R)-ethyl 6-methyl-2-oxo-4-phenyl-3,4-dihydro-2H-pyran-5-carboxylate

Refernces

• 1、 Lee, Cayo,Sammis, Glenn M.,Thomson, Brodie J.. "Rapid and column-free syntheses of acyl fluorides and peptides usingex situgenerated thionyl fluoride". . p. 188 - 194. Retrieved 2021/12/31.
• 2、 Barbasiewicz, Micha?,Tryniszewski, Micha?. "Gram-Scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles". . . Retrieved 2021/11/30.