ethyl 2-(4-bromophenyl)-4-quinolinecarboxylate

Base Information

• Chemical Name: ethyl 2-(4-bromophenyl)-4-quinolinecarboxylate
• CAS No.: 351982-02-0
• Molecular Formula: C18H14BrNO2
• Molecular Weight: 356.219
• Mol file: 351982-02-0.mol

Synonyms:2-(4-bromo-phenyl)-quinoline-4-carboxylic acid ethyl ester;2-(4-Brom-phenyl)-chinolin-4-carbonsaeure-aethylester;

Chemical Property of ethyl 2-(4-bromophenyl)-4-quinolinecarboxylate

Chemical Property:

• PSA: 39.19000
• LogP: 4.84100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-bromophenyl)-4-quinolinecarboxylate

There total 9 articles about ethyl 2-(4-bromophenyl)-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-hydroxypropionate (97-64-3,2676-33-7) + 4-bromo-benzaldehyde (1122-91-4) + aniline (62-53-3) → ethyl 2-(4'-bromophenyl)-quinoline-4-carboxylate (351982-02-0)

Guidance literature:

With iron(III) chloride; at 110 ℃; for 12h; Green chemistry;

DOI:10.1039/d0gc00738b

Reference yield:

ethanol (64-17-5) + 2-(4'-bromophenyl)quinoline-4-carboxylic acid (103914-52-9) → ethyl 2-(4'-bromophenyl)-quinoline-4-carboxylate (351982-02-0)

Guidance literature:

With sulfuric acid; for 12h; Reflux;

DOI:10.3390/molecules24071274

Reference yield:

2-(4'-bromophenyl)quinoline-4-carboxylic acid (103914-52-9) → ethyl 2-(4'-bromophenyl)-quinoline-4-carboxylate (351982-02-0)

Guidance literature:

With thionyl chloride; Behandeln des Reaktionsprodukts mit Aethanol;

DOI:10.1021/ja01216a087

upstream raw materials:

2-(4'-bromophenyl)quinoline-4-carboxylic acid

2-methoxyacrylic acid ethyl ester

(E)-1-(4-bromophenyl)-N-phenylmethanimine

4-bromo-benzaldehyde

Downstream raw materials:

[2-(4-bromo-phenyl)-[4]quinolyl]-carbamic acid ethyl ester

Refernces

• 1、 Hamdy, Rania,Elseginy, Samia A.,Ziedan, Noha I.,Jones, Arwyn T.,Westwell, Andrew D.. "New quinoline-based heterocycles as anticancer agents targeting Bcl-2". . . Retrieved 2019/04/05.