19-CARBOXYANDROST-4-ENE-3,17-DIONE

Base Information

• Chemical Name: 19-CARBOXYANDROST-4-ENE-3,17-DIONE
• CAS No.: 4757-95-3
• Molecular Formula: C19H24O4
• Molecular Weight: 316.397
• Mol file: 4757-95-3.mol

Synonyms:Androst-4-ene-3,17-dion-19-oicacid;19-Oic-androstenedione;Androst-4-en-19-oic acid, 3,17-dioxo-;3,17-dioxoandrost-4-en-19-oic acid;

Chemical Property of 19-CARBOXYANDROST-4-ENE-3,17-DIONE

Chemical Property:

• Vapor Pressure: 2.11E-12mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 524.4 °C at 760 mmHg
• Flash Point: 285 °C
• PSA: 71.44000
• Density: 1.26 g/cm³
• LogP: 3.15210

Purity/Quality:

99% ^*data from raw suppliers

3,17-Dioxo-19-carboxy-androst-4-ene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Testosterone derivative Exemestane intermediate.

Technology Process of 19-CARBOXYANDROST-4-ENE-3,17-DIONE

There total 6 articles about 19-CARBOXYANDROST-4-ENE-3,17-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

19-oxoandrostenedione (968-49-0) → androst-4-ene-3,17-dion-19-oic acid (4757-95-3)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; tert-butyl alcohol; at 20 ℃; for 2.5h; Solvent;

Reference yield: 48.0%

19-hydroxy-4-androstene-3,17-dione (510-64-5) → androst-4-ene-3,17-dion-19-oic acid (4757-95-3)

Guidance literature:

With jones reagent; In acetone;

DOI:10.1016/S0039-128X(99)00108-7

Reference yield:

→ 3,17-Dioxo-19-carboxy-androsten-(4) (4757-95-3,148261-62-5)

Guidance literature:

19-Hydroxy-3,17-dioxo-androsten-(4) XIII, CrO3, Acn.;

DOI:10.1021/ja00875a046

upstream raw materials:

19-hydroxy-4-androstene-3,17-dione

19-oxoandrostenedione

Downstream raw materials:

estra-5⁽¹⁰⁾-en-3,17-dione

3,3-(ethylenedioxy)-5(10)-estren-17-one

3,3-dimethoxyestr-5(10)-en-17-one

3,3-dimethoxyestr-5(10)-en-17β-ol

Refernces

• 1、 Templeton, John F.,Majgier-Baranowska, Helena,Marat, Kirk. "Steroid dimer formation: Metal reduction of methyl androst-4-ene-3,17-dion-19-oate". . p. 219 - 223. Retrieved 2007/10/03.
• 2、 Watanabe, Yoshihito,Ishimura, Yuzuru. "A Model Study on Aromatase Cytochrome P-450 Reaction: Transformation of Androstene-3,17,19-trione to 10β-Hydroxyestr-4-ene-3,17-dione". . p. 8047 - 8049. Retrieved 2007/10/02.