4-ISOPROPYL-BENZOIC ACID HYDRAZIDE

Base Information

• Chemical Name: 4-ISOPROPYL-BENZOIC ACID HYDRAZIDE
• CAS No.: 5351-24-6
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• Hs Code.: 2928000090
• Mol file: 5351-24-6.mol

Synonyms:Benzoicacid, p-isopropyl-, hydrazide (6CI);(p-Isopropylbenzoyl)hydrazine;NSC 648;p-Isopropylbenzoic acid hydrazide;4-(Propan-2-yl)benzohydrazide;4-Isopropyl-benzoic acid hydrazide;

Chemical Property of 4-ISOPROPYL-BENZOIC ACID HYDRAZIDE

Chemical Property:

• Melting Point: 91-92 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• Refractive Index: 1.546
• PKA: 12.77±0.10(Predicted)
• PSA: 55.12000
• Density: 1.067 g/cm³
• LogP: 2.50470

Purity/Quality:

99% ^*data from raw suppliers

4-Isopropyl-benzoicAcidHydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Isopropyl-benzoic Acid Hydrazide is a useful chemical reagent.Also, it is used in the synthesis of 2-Chloropyridine derivative which exhibits the most potent activity against gastric cancer cell SGC-7901.

Technology Process of 4-ISOPROPYL-BENZOIC ACID HYDRAZIDE

There total 5 articles about 4-ISOPROPYL-BENZOIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-isopropylbenzoyl chloride (21900-62-9) → 4-isopropylbenzoic acid hydrazide (5351-24-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

DOI:10.3390/molecules25061463

Reference yield:

p-isopropylbenzoic acid (536-66-3) → 4-isopropylbenzoic acid hydrazide (5351-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2013.02.008

Reference yield:

p-isopropylbenzoic acid methyl ester (20185-55-1) → 4-isopropylbenzoic acid hydrazide (5351-24-6)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

p-isopropylbenzoic acid methyl ester

ethyl 4-isopropylbenzoate

p-isopropylbenzoic acid

p-isopropylbenzoyl chloride

Downstream raw materials:

5-(4-isopropylphenyl)-1,3,4-oxadiazole-2-thiol

2-(4-Isopropylphenyl)-5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazole

5-(4-isopropylphenyl)-1,3,4-oxadiazol-2(3H)-one

Refernces

• 1、 Soliman, Sameh S.M.,Hamdy, Rania,Elseginy, Samia A.,Gebremariam, Teclegiorgis,Hamoda, Alshaimaa M.,Madkour, Mohamed,Venkatachalam, Thenmozhi,Ershaid, Mai N.,Mohammad, Mohammad G.,Chamilos, Georgios,Ibrahim, Ashraf S.. "Selective inhibition of Rhizopus eumelanin biosynthesis by novel natural product scaffold-based designs caused significant inhibition of fungal pathogenesis". . p. 2489 - 2507. Retrieved 2020/09/02.
• 2、 De Azevedo, Ricardo Alexandre,Ferreira, Adilson Kleber,Jorge, Salomo Dria,Palace-Berl, Fanny,Pasqualoto, Kerly Fernanda Mesquita,Silva, Marcelo Nunes,Tavares, Leoberto Costa,Teixeira, Sarah Fernandes,Zingales, Bianca,Zorzi, Rodrigo Rocha. "Designing and exploring active N′-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients". . p. 330 - 339. Retrieved 2015/04/27.