4-Fluorobenzhydrazide

Base Information

• Chemical Name: 4-Fluorobenzhydrazide
• CAS No.: 456-06-4
• Molecular Formula: C7H7FN2O
• Molecular Weight: 154.144
• Hs Code.: 29280000
• European Community (EC) Number: 610-264-4
• DSSTox Substance ID: DTXSID30196561
• Nikkaji Number: J83.411D
• Wikidata: Q72479131
• Mol file: 456-06-4.mol

Synonyms:4-Fluorobenzhydrazide;4-Fluorobenzohydrazide;456-06-4;4-Fluorobenzoic hydrazide;p-Fluorobenzoic acid hydrazide;p-Fluorobenzoylhydrazine;4-fluorobenzoic acid hydrazide;Benzoic acid, 4-fluoro-, hydrazide;Hydrazine, (p-fluorobenzoyl)-;4-Fluorobenzoylhydrazine;BENZOIC ACID, p-FLUORO-, HYDRAZIDE;4-Fluorobenzhydrazide,;MFCD00060562;BRN 1946324;4-fluoro-benzoic acid hydrazide;4-09-00-00955 (Beilstein Handbook Reference);4-fluoro benzoyl hydrazine;4-fluorobenzenecarbohydrazide;4-Fluorobenzoichydrazide;4-fluoro-benzhydrazide;4-fluoro-benzohydrazide;4-Fluorobenzohydrazide #;SCHEMBL222973;4-Fluorobenzoic hydrazide, 96%;DTXSID30196561;JS-044C;STK074196;AKOS000116244;CS-W022181;SB85944;LS-37457;SY007335;UPCMLD0ENAT0511-4819:001;BB 0240957;F0540;FT-0632158;EN300-03624;A826859;J-515399;Z56862389;F3374-0929;1-(dichloromethyl)-4-fluoro-benzene;4-Fluorobenzoic Hydrazide

Chemical Property of 4-Fluorobenzhydrazide

Chemical Property:

• Appearance/Colour: off-white to tan solid
• Vapor Pressure: 0.392mmHg at 25°C
• Melting Point: 162-166 °C(lit.)
• Refractive Index: 1.524
• Boiling Point: 299.8 °C at 760 mmHg
• PKA: 12.17±0.10(Predicted)
• Flash Point: 135.1 °C
• PSA: 55.12000
• Density: 1.272 g/cm³
• LogP: 1.52040
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Soluble in methanol.
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 154.05424101
• Heavy Atom Count: 11
• Complexity: 143

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluorobenzoic hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)NN)F
• Uses: Used in the stnthesis of fluorinated poly (1, 3, 4-oxadiazole-ether-imide). N-(3,5-dinitrobenzoyl)-N?-(4-fluorobenzoyl)-hydrazine with 4-Fluorobenzhydrazide as solvent in NMP.

Technology Process of 4-Fluorobenzhydrazide

There total 11 articles about 4-Fluorobenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluorobenzoic acid ethyl ester (451-46-7) → 4-fluorobenzoyl hydrazide (456-06-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 - 85 ℃; for 10h; Reflux;

Reference yield: 100.0%

→ 4-fluorobenzoyl hydrazide (456-06-4)

Guidance literature:

Reference yield: 97.0%

4-Fluorobenzoic acid (456-22-4) → 4-fluorobenzoyl hydrazide (456-06-4)

Guidance literature:

4-Fluorobenzoic acid; With sulfuric acid; In ethanol; for 6h; Reflux;

With hydrazine hydrate; sodium hydrogencarbonate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2017.06.036

upstream raw materials:

4-fluorobenzoic acid ethyl ester

methyl 4-flurobenzoate

phenyl 4-fluorobenzoate

4-Fluorobenzoic acid

Downstream raw materials:

4-Fluoro-benzoic acid [5-chloro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

4-Fluoro-benzoic acid [5-bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide

N’-(2-oxo-1,2-dihydro-indol-3-ylidene)-4-fluorobenzohydrazide

4-fluoro-N-[(methylcarbamoyl)amino]benzamide

Refernces

• 1、 Liu, Jie,Zhang, Guang-Yu,Zhang, Zhe,Li, Bo,Chai, Fei,Wang, Qi,Zhou, Zi-Dan,Xu, Ling-Ling,Wang, Shou-Kai,Jin, Zhen,Tang, You-Zhi. "Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker". . . Retrieved 2021/05/17.
• 2、 Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun. "Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles". . p. 11572 - 11581. Retrieved 2021/10/12.