(2E)-[(4E)-4-(hydroxyimino)cyclohexa-2,5-dien-1-ylidene](4-methoxyphenyl)ethanenitrile

Base Information

• Chemical Name: (2E)-[(4E)-4-(hydroxyimino)cyclohexa-2,5-dien-1-ylidene](4-methoxyphenyl)ethanenitrile
• CAS No.: 3122-39-2
• Molecular Formula: C15H12 N2 O2
• Molecular Weight: 252.268
• Mol file: 3122-39-2.mol

Synonyms:2,5-Cyclohexadiene-D1,a-acetonitrile, a-(p-methoxyphenyl)-4-oxo-, oxime (6CI,7CI,8CI); NSC405166

Chemical Property of (2E)-[(4E)-4-(hydroxyimino)cyclohexa-2,5-dien-1-ylidene](4-methoxyphenyl)ethanenitrile

Chemical Property:

• Vapor Pressure: 4.67E-09mmHg at 25°C
• Boiling Point: 454.7°Cat760mmHg
• Flash Point: 228.8°C
• Density: 1.13g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-[(4E)-4-(hydroxyimino)cyclohexa-2,5-dien-1-ylidene](4-methoxyphenyl)ethanenitrile

There total 3 articles about (2E)-[(4E)-4-(hydroxyimino)cyclohexa-2,5-dien-1-ylidene](4-methoxyphenyl)ethanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

nitrobenzene (98-95-3,26969-40-4) + p-methoxybenzylnitrile (104-47-2) → (4-Hydroxyimino-cyclohexa-2,5-dienylidene)-(4-methoxyphenyl)-acetonitrile (3122-39-2)

Guidance literature:

In water; at 20 ℃; for 0.666667h; Milling; Green chemistry;

DOI:10.1039/c5ra23606a

Reference yield:

nitrobenzene (98-95-3,26969-40-4) + p-methoxybenzylnitrile (104-47-2) → α-<4-Methoxy-phenyl>-4-oxo-cyclohexadien-(2,5)-Δ1,α-acetonitril-oxim (3122-39-2)

Guidance literature:

With potassium hydroxide; In methanol;

Reference yield:

→ α-<4-Methoxy-phenyl>-4-oxo-cyclohexadien-(2,5)-Δ1,α-acetonitril-oxim (3122-39-2)

Guidance literature:

Nitrobenzol, p-Methoxybenzylcyanid, methanol. KOH;

DOI:10.1021/ja01496a058

upstream raw materials:

nitrobenzene

p-methoxybenzylnitrile

Downstream raw materials:

(4-Methylsulfonyloxyimino-cyclohexa-2,5-dienylidene)-(4-methoxyphenyl)-acetonitrile

2-(4-N'-Benzylaminophenyl)-2-(4-methoxyphenyl)ethylamin

(4-(4-Methylphenylsulfonyloxyimino)-cyclohexa-2,5-dienylidene)-(4-methoxyphenyl)-acetonitrile

2-(4-N-Ethylaminophenyl)-2-(4-methoxyphenyl)ethylamin

Refernces

• 1、 Dore Ch.,Viel. "Antitumor chemotherapy. XIV. Cytotoxic activity of compounds possessing an ethylenic double bond substituted at the α and β positions with an electron attracting group". . p. 47 - 54. Retrieved 2007/10/04.