L-Leucyl-Hydroxylamine

Base Information

• Chemical Name: L-Leucyl-Hydroxylamine
• CAS No.: 31982-78-2
• Molecular Formula: C₆H₁₄N₂O₂
• Molecular Weight: 146.189
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID70185818
• Nikkaji Number: J406.881E
• Wikidata: Q27094237
• Metabolomics Workbench ID: 147835
• ChEMBL ID: CHEMBL303296
• Mol file: 31982-78-2.mol

Synonyms:L-leucine hydroxamate;leucine hydroxamate

Chemical Property of L-Leucyl-Hydroxylamine

Chemical Property:

• Melting Point: 195-200 °C (decomp)
• Refractive Index: 1.479
• PKA: 10.11±0.40(Predicted)
• PSA: 78.84000
• Density: 1.079 g/cm³
• LogP: 1.40580
• Storage Temp.: -15°C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 146.105527694
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Amino-N-hydroxy-4-methylpentanimidicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NO)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)NO)N

Technology Process of L-Leucyl-Hydroxylamine

There total 5 articles about L-Leucyl-Hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Leucin-hydroxymsaeure-benzylester (16707-89-4) → L-Leucine hydroxamate (31982-78-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 29420.3 Torr;

DOI:10.1021/jo01034a010

Reference yield:

L-Leucine ethyl ester (2743-60-4,75023-21-1) → L-Leucine hydroxamate (31982-78-2)

Guidance literature:

With hydroxylamine; In methanol;

DOI:10.1021/jo01034a010

Reference yield:

H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7) → L-Leucine hydroxamate (31982-78-2)

Guidance literature:

With hydroxylamine; In aq. buffer; at 40 ℃; for 3h; pH=7.2; Solvent; Time; Concentration; Kinetics; Micellar solution; Enzymatic reaction;

DOI:10.1016/j.molcatb.2013.03.016

upstream raw materials:

L-Leucine ethyl ester

L-Leucin-hydroxymsaeure-benzylester

H-L-Leu-NH₂

Refernces

• 1、 Bird, Kathleen,Bourne, Samuel,Brandel, Jeremy,Duce, James A.,El Fallah, Rawa,Hubscher-Bruder, Véronique,Lewis, Frank W.,Maina, Mahmoud,Navarro, Jean-Philippe,Pienaar, Ilse S.,Tétard, David,Tsatsanis, Andrew. "Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1 H)-one iron chelators in an in vitro cell model of Parkinson's disease". supporting information. p. 3590 - 3603. Retrieved 2022/03/14.