1,1-Diethoxy-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1,1-Diethoxy-N,N-dimethylmethanamine
• CAS No.: 1188-33-6
• Molecular Formula: C7H17NO2
• Molecular Weight: 147.217
• Hs Code.: 29225000
• European Community (EC) Number: 214-707-9
• NSC Number: 377652
• UNII: QOJ5HYK225
• DSSTox Substance ID: DTXSID5061584
• Nikkaji Number: J150.716H
• Wikidata: Q72468734
• Mol file: 1188-33-6.mol

Synonyms:1188-33-6;1,1-Diethoxy-N,N-dimethylmethanamine;N,N-Dimethylformamide diethyl acetal;1,1-Diethoxytrimethylamine;N,N-Dimethyformamide diethy acetal;Methanamine, 1,1-diethoxy-N,N-dimethyl-;dimethylformamide diethylacetal;(diethoxymethyl)dimethylamine;Diethoxy-N,N-dimethylmethanamine;N,N-Dimethylformamide diethylacetal;QOJ5HYK225;1,1-Diethoxy trimethyl amine;EINECS 214-707-9;NSC 377652;NSC-377652;AI3-36612;1,1-Diethoxy-N,N-dimethylmethylamine;MFCD00009227;NSC377652;1,1-diethoxy-N,N-dimethyl-methanamine;diethoxymethyldimethylamine;UNII-QOJ5HYK225;diethoxymethyl-dimethyl-amine;C(OCC)(OCC)N(C)C;dimethylformamide-diethylacetal;SCHEMBL131012;Dimethylformamide diethyl acetal;Trimethylamine, 1,1-diethoxy-;dimethyl formamide diethyl acetal;DTXSID5061584;BWKAYBPLDRWMCJ-UHFFFAOYSA-;Diethoxy-N,N-dimethylmethanamine #;BCP24538;n,n-dimethyl formamide diethylacetal;n,n-dimethyl-formamide diethylacetal;n,n-dimethylformamide diethyl-acetal;N,N-dimethyl-formamide-diethylacetal;N,N-dimethylformamide-diethyl-acetal;N,N-dimethyl formamide diethyl acetal;N,N-dimethyl formamide-diethyl acetal;N,N-dimethyl-formamide diethyl acetal;AKOS005259142;CS-W018204;AS-41067;FLUMAZENIL IMPURITY C [EP IMPURITY];N,N-Dimethylformamide diethyl acetal, 95%;A2463;D1294;FT-0629536;EN300-136269;FORMAMIDE, N,N-DIMETHYL-, DIETHYL ACETAL;W-108533;DIMETHYLFORMAMIDE DIETHYLACETAL [USP IMPURITY];F0001-0302;Z1255360389;N,N-Dimethylformamide diethyl acetal, for GC derivatization;N,N-Dimethylformamide diethyl acetal, for GC derivatization, >=98.0% (GC)

Chemical Property of 1,1-Diethoxy-N,N-dimethylmethanamine

Chemical Property:

• Appearance/Colour: Clear colorless to yellowish liquid
• Vapor Pressure: 5.76mmHg at 25°C
• Melting Point: 178-180 °C(Solv: ethanol (64-17-5))
• Refractive Index: n20/D 1.411(lit.)
• Boiling Point: 130.3 °C at 760 mmHg
• PKA: 5.31±0.50(Predicted)
• Flash Point: 22.2 °C
• PSA: 21.70000
• Density: 0.859 g/cm³
• LogP: 0.90460
• Storage Temp.: Store below +30°C.
• Sensitive.: Moisture Sensitive
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 147.125928785
• Heavy Atom Count: 10
• Complexity: 70

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethylformamide diethyl acetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: CCOC(N(C)C)OCC
• Uses: N,N-Dimethylformamide diethyl acetal was used in quantification of cocaine and its primary metabolite, benzoyl ecgonine from urine matrix by gas chromatography. N,N-Dimethylformamide diethyl acetal is a suitable reagent for the esterification of fatty acids. It is suitable reagent used in the quantification of cocaine and its primary metabolite, benzoyl ecgonine, from a urine matrix by gas chromatography.

Technology Process of 1,1-Diethoxy-N,N-dimethylmethanamine

There total 13 articles about 1,1-Diethoxy-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethylaminodiethoxycarbonium tetrafluoroborate → ethyl N,N-dimethylcarbamate (687-48-9) + N,N-dimethylformamide diethyl diacetal (1188-33-6)

Guidance literature:

With Trimethyl borate; sodium hydride; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

→ hydrogen fluoride (7664-39-3,12381-92-9,32057-09-3,74835-82-8) + N,N-dimethylformamide diethyl diacetal (1188-33-6)

Guidance literature:

Reference yield:

N,N,N,N-tetramethyldiamino ethoxycarbonium tetrafluoroborate → ethoxy-bis-(dimethylamino)-methane (5815-07-6) + N,N-dimethylformamide diethyl diacetal (1188-33-6)

Guidance literature:

With Trimethyl borate; sodium hydride; In tetrahydrofuran; at 20 ℃; for 24h; Title compound not separated from byproducts;

upstream raw materials:

ethanol

Vilsmeier reagent

(methoxymethylidene)dimethylammonium methyl sulfate

1,1-dichloromethyl-N,N-dimethylamine

Downstream raw materials:

N,N-dimethyl-N'-(5-m-tolyl-[1,3,4]oxadiazol-2-yl)-formamidine

ethyl 2-cyano-2-methylbutanoate

(p-Dimethylaminophenylimino)-ethylmercapto-N,N-dimethylacetamid

N,N-dimethyl-N'-p-tolylformimidamide

Refernces

• 1、 Kantlehner, Willi,Stieglitz, Ruediger,Hauber, Michael,Haug, Erwin,Regele, Claudia. "Orthoamides. LII. Contributions to the synthesis of carboxylic ortho acid amides". . p. 256 - 268. Retrieved 2007/10/03.