Nalpha-[(2-chloroethyl)(nitroso)carbamoyl]-N-phenylphenylalaninamide

Base Information

• Chemical Name: Nalpha-[(2-chloroethyl)(nitroso)carbamoyl]-N-phenylphenylalaninamide
• CAS No.: 80687-19-0
• Molecular Formula: C₁₈H₁₉ClN₄O₃
• Molecular Weight: 374.827
• Mol file: 80687-19-0.mol

Synonyms:

Chemical Property of Nalpha-[(2-chloroethyl)(nitroso)carbamoyl]-N-phenylphenylalaninamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.28g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Nalpha-[(2-chloroethyl)(nitroso)carbamoyl]-N-phenylphenylalaninamide

There total 2 articles about Nalpha-[(2-chloroethyl)(nitroso)carbamoyl]-N-phenylphenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N--L-phenylalanine (74729-50-3,52322-29-9) + aniline (62-53-3) → N2--(L)-phenylalaninanilide (80687-19-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 1.5h; Yield given; Ambient temperature;

DOI:10.1055/s-1987-28160

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N2--(L)-phenylalaninanilide (80687-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dioxane; H₂O / 3 h / Ambient temperature

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 1.5 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water;

DOI:10.1055/s-1987-28160

upstream raw materials:

N--L-phenylalanine

aniline

L-phenylalanine

Refernces

• 1、 Tang,Eisenbrand. "Synthesis of potentially antineoplastic derivatives of N-[N-(2-chloroethyl)-N-nitrosocarbamoyl]amino acids". . p. 910 - 917. Retrieved 2007/10/02.