propan-2-yl 3-(propan-2-yloxy)propanoate

Base Information

• Chemical Name: propan-2-yl 3-(propan-2-yloxy)propanoate
• CAS No.: 4220-74-0
• Molecular Formula: C9H18O3
• Molecular Weight: 174.24
• Mol file: 4220-74-0.mol

Synonyms:

Chemical Property of propan-2-yl 3-(propan-2-yloxy)propanoate

Chemical Property:

• Vapor Pressure: 0.128mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of propan-2-yl 3-(propan-2-yloxy)propanoate

There total 3 articles about propan-2-yl 3-(propan-2-yloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + isopropyl alcohol (67-63-0,8013-70-5) → methyl 3-methoxypropionate (3852-09-3) + isopropyl acrylate (689-12-3) + isopropyl 3-methoxypropionate (10500-14-8) + 3-isopropoxy-propionic acid isopropyl ester (4220-74-0)

Guidance literature:

With n-butyllithium; bis(acetylacetonate)nickel(II); In benzene; at 90 ℃; for 5h; Product distribution; other temp, other time;

Reference yield:

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + isopropyl alcohol (67-63-0,8013-70-5) → isopropyl propionate (637-78-5) + 3-isopropoxy-propionic acid isopropyl ester (4220-74-0)

Guidance literature:

With [Cp(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)Ru(pyridine)₂][PF₆]; potassium tert-butylate; at 70 ℃; for 8h; Glovebox; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.organomet.5b00967

Reference yield:

isopropyl alcohol (67-63-0,8013-70-5) + ethyl acrylate (140-88-5,9003-32-1) → isopropyl propionate (637-78-5) + 3-isopropoxy-propionic acid isopropyl ester (4220-74-0)

Guidance literature:

With [Cp(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)Ru(pyridine)₂][PF₆]; potassium tert-butylate; at 70 ℃; for 16h; Glovebox; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.organomet.5b00967

upstream raw materials:

acrylic acid methyl ester

isopropyl alcohol

ethyl acrylate

Refernces

• 1、 Helms, Manfred,Fuellbier, Harry. "A Contribution to the Nickelcatalyzed Transesterification and to the Addition of Acrylic Acid Methylester to Alcohols". . p. 643 - 647. Retrieved 2007/10/02.