Cyclohexanemethanol, 1-(dimethylamino)-

Base Information

• Chemical Name: Cyclohexanemethanol, 1-(dimethylamino)-
• CAS No.: 4368-61-0
• Molecular Formula: C9H19NO
• Molecular Weight: 157.256
• Mol file: 4368-61-0.mol

Synonyms:

Chemical Property of Cyclohexanemethanol, 1-(dimethylamino)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanemethanol, 1-(dimethylamino)-

There total 5 articles about Cyclohexanemethanol, 1-(dimethylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 1-(dimethylamino)-1-cyclohexanecarboxylate → 1-(dimethylamino)-1-cyclohexanecarbinol (4368-61-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Heating;

Reference yield:

formaldehyde(methanol 44%, water 10%) (71481-64-6) + (1-nitrocyclohexyl)methanol (3719-52-6) → 1-(dimethylamino)-1-cyclohexanecarbinol (4368-61-0)

Guidance literature:

(1-nitrocyclohexyl)methanol; With hydrogen; raney nickel (R-3111); In methanol; at 100 ℃; for 3.5h; under 25858.1 - 38787.1 Torr; Inert atmosphere; Sealed reactor;

formaldehyde(methanol 44%, water 10%); In methanol; at 100 ℃; for 7.75h; under 36201.3 - 38787.1 Torr;

Reference yield:

(1-aminocyclohexyl)methanol (4313-56-8) + methyl iodide (74-88-4) → 1-(dimethylamino)-1-cyclohexanecarbinol (4368-61-0)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; for 24h;

upstream raw materials:

formaldehyd

(1-aminocyclohexyl)methanol

formaldehyde(methanol 44%, water 10%)

(1-nitrocyclohexyl)methanol

Downstream raw materials:

4-Amino-benzoic acid 1-dimethylamino-cyclohexylmethyl ester

4-Nitro-benzoic acid 1-dimethylamino-cyclohexylmethyl ester

Refernces

• 1、 -. "APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES". Paragraph 1855. . Retrieved 2013/04/24.
• 2、 Aboul-Enein, M. N.,El-Azzouny, A. A.,Abdallah, N. A.,Makhlouf, A. A.. "Synthesis and Local Anaesthetic Activity of Certain Basic Esters of 1-Dialkyl Amino Cyclohexyl Carbinols". . p. 549 - 558. Retrieved 2007/10/02.