CYCLOHEXYLTRIFLUOROACETONE

Base Information

• Chemical Name: CYCLOHEXYLTRIFLUOROACETONE
• CAS No.: 457-49-8
• Molecular Formula: C9H13F3O
• Molecular Weight: 194.197
• Hs Code.: 2914700090
• Mol file: 457-49-8.mol

Synonyms:2-Propanone,3-cyclohexyl-1,1,1-trifluoro;trifluoro-1,1,1 cyclohexyl-3 propanone;3-cyclohexyl-1,1,1-trifluoro-acetone;CYCLOHEXYLTRIFLUOROACETONE;3-Cyclohexyl-1,1,1-trifluor-aceton;cyclohexylmethyl trifluoromethyl ketone;

Chemical Property of CYCLOHEXYLTRIFLUOROACETONE

Chemical Property:

• Vapor Pressure: 0.574mmHg at 25°C
• Boiling Point: 189.3oC at 760 mmHg
• Flash Point: 85.9oC
• PSA: 17.07000
• Density: 1.115g/cm3
• LogP: 3.08820

Purity/Quality:

98%min ^*data from raw suppliers

Cyclohexyltrifluoroacetone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOHEXYLTRIFLUOROACETONE

There total 10 articles about CYCLOHEXYLTRIFLUOROACETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoro-1,1,1 cyclohexyl-3 trimehylsilyloxy-2 propene-2 (122977-62-2) → 3-cyclohexyl-1,1,1-trifluoropropan-2-one (457-49-8)

Guidance literature:

With hydrogen fluoride; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0022-1139(00)82782-7

Reference yield: 49.0%

1-cyclohexyl-3,3,3-trifluoro-2-propanol → 3-cyclohexyl-1,1,1-trifluoropropan-2-one (457-49-8)

Guidance literature:

With DBN; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 4h; Sealed tube;

DOI:10.1021/jo301477s

Reference yield:

oxime de la trifluoro-methyl benzyl cetone (348-73-2) → 3-cyclohexyl-1,1,1-trifluoropropan-2-one (457-49-8)

Guidance literature:

With hydrogenchloride; ethanol; platinum; at 140 ℃; under 73550.8 - 88260.9 Torr; Hydrogenation;

DOI:10.1021/ja01168a012

upstream raw materials:

oxime de la trifluoro-methyl benzyl cetone

trifluoro-1,1,1 cyclohexyl-3 trimehylsilyloxy-2 propene-2

Cyclohexylmethylen-triphenyl-phosphoran

Triphenyl-hexahydrobenzyl-phosphonium

Downstream raw materials:

2-cyclohexyl-1-trifluoromethyl-ethylamine

2-(cyclohexylmethyl)-1,1,1-trifluorobutan-2-ol

3-cyclohexyl-1,1,1-trifluoro-2-((trimethylsilyl)methyl)propan-2-ol

(2-(trifluoromethyl)allyl)cyclohexane

Refernces

• 1、 Rudzinski, Diandra M.,Kelly, Christopher B.,Leadbeater, Nicholas E.. "A Weinreb amide approach to the synthesis of trifluoromethylketones". . p. 9610 - 9612. Retrieved 2012/10/29.
• 2、 Begue, J. P.,Mesureur, D.. "NOUVELLE SYNTHESE DE TRIFLUOROMETHYLCETONES ET D' α-BROMO TRIFLUOROMETHYLCETONES". . p. 271 - 282. Retrieved 2007/10/02.