N-Methyl-3-pyridinamine

Base Information

• Chemical Name: N-Methyl-3-pyridinamine
• CAS No.: 18364-47-1
• Molecular Formula: C6H8 N2
• Molecular Weight: 108.143
• Hs Code.: 29333990
• Mol file: 18364-47-1.mol

Synonyms:Pyridine,3-(methylamino)- (6CI,8CI); 3-(Methylamino)pyridine;N-(Pyridin-3-yl)-N-methylamine; N-Methyl-3-aminopyridine; N-Methyl-3-pyridinamine

Chemical Property of N-Methyl-3-pyridinamine

Chemical Property:

• Vapor Pressure: 0.165mmHg at 25°C
• Melting Point: 201 °C
• Refractive Index: 1.5840 to 1.5880
• Boiling Point: 213.3 °C at 760 mmHg
• PKA: pK1:8.70(＋1) (30°C)
• Flash Point: 82.8 °C
• PSA: 24.92000
• Density: 1.059 g/cm³
• LogP: 1.19630
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%, ^*data from raw suppliers

N-Methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-3-pyridinamine

There total 23 articles about N-Methyl-3-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

pyridin-3-ylamine (462-08-8) + methanol (67-56-1) → N-methyl-N-(3-pyridyl)amine (18364-47-1)

Guidance literature:

With 30%Cu-5%Ni/Al₂O₃ ; at 320 ℃; Reagent/catalyst; Inert atmosphere;

Reference yield: 98.5%

pyridin-3-ylamine (462-08-8) + carbon monoxide (201230-82-2) → N-methyl-N-(3-pyridyl)amine (18364-47-1)

Guidance literature:

With hydrogen; at 230 ℃;

Reference yield: 97.5%

pyridin-3-ylamine (462-08-8) + Dimethyl ether (115-10-6,157621-61-9) → N-methyl-N-(3-pyridyl)amine (18364-47-1)

Guidance literature:

With 20%Ni-5%Mo/Al₂O₃ ; at 320 ℃; Inert atmosphere;

upstream raw materials:

3-Chloropyridine

3-Bromopyridine

methylamine

4-methyl-N-(pyridine-3-yl)benzenesulfonamide

Downstream raw materials:

N-methyl-N-pyridin-3-yl-benzamide

3-nitrosomethylaminopyridine

(2,6-dibromo-[3]pyridyl)-methyl-amine

2-amino-3-methylaminopyridine

Refernces

• 1、 -. "Method for catalyzing N-alkylation of aminopyridine". Paragraph 0087-0091. . Retrieved 2021/08/07.
• 2、 Feng, Xinshu,Huang, Ming. "Effect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols". . . Retrieved 2021/06/21.