7-O-Methylluteolin

Base Information

• Chemical Name: 7-O-Methylluteolin
• CAS No.: 20243-59-8
• Molecular Formula: C16H12 O6
• Molecular Weight: 300.268
• Hs Code.: 2932999099
• UNII: 732GA1Z079
• Nikkaji Number: J94.511K
• Wikidata: Q27266123
• Metabolomics Workbench ID: 24128
• ChEMBL ID: CHEMBL183745
• Mol file: 20243-59-8.mol

Synonyms:hydroxygenkwanin

Chemical Property of 7-O-Methylluteolin

Chemical Property:

• Vapor Pressure: 6.45E-14mmHg at 25°C
• Melting Point: 225-227oC
• Boiling Point: 571.9°Cat760mmHg
• PKA: 6.33±0.40(Predicted)
• Flash Point: 218.4°C
• PSA: 100.13000
• Density: 1.538g/cm³
• LogP: 2.58540
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 300.06338810
• Heavy Atom Count: 22
• Complexity: 462

Purity/Quality:

98% ^*data from raw suppliers

hydroxygenkwanin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)O)O

Technology Process of 7-O-Methylluteolin

There total 29 articles about 7-O-Methylluteolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one → 7-methylluteoline (20243-59-8)

Guidance literature:

With acetic acid; In water; at 190 ℃; for 1h; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1371/journal.pone.0153112

Reference yield: 50.0%

C22H18O9 → 7-methylluteoline (20243-59-8)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; for 1.5h; Reflux;

DOI:10.1002/chem.202001264

Reference yield: 43.0%

C37H30O6 → 7-methylluteoline (20243-59-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 12h;

DOI:10.3390/molecules26103033

upstream raw materials:

2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on

dimethyl sulfate

2-(3,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-4H-chromen-4-one

2-(3,4-dihydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one

Refernces

• 1、 Choe, Jung-Won,Heo, Hee-Young,Jung, Se-Hui,Kim, Jaehyun,Lee, Kooyeon. "Anti‐melanogenic properties of velutin and its analogs?". . . Retrieved 2021/06/03.
• 2、 Yamauchi, Kosei,Fujieda, Akari,Mitsunaga, Tohru. "Selective synthesis of 7-O-substituted luteolin derivatives and their melanonenesis and proliferation inhibitory activity in B16 melanoma cells". . p. 2518 - 2522. Retrieved 2018/06/20.