2,2'-Pyridil

Base Information

• Chemical Name: 2,2'-Pyridil
• CAS No.: 492-73-9
• Molecular Formula: C12H8N2O2
• Molecular Weight: 212.208
• European Community (EC) Number: 207-759-9
• NSC Number: 16545
• DSSTox Substance ID: DTXSID90197711
• Nikkaji Number: J66C
• Wikidata: Q72469518
• Pharos Ligand ID: PUMQXPDYFBYB
• ChEMBL ID: CHEMBL373345
• Mol file: 492-73-9.mol

Synonyms:2,2'-Pyridil;492-73-9;Di-2-pyridylglyoxal;Bipicolinoyl;1,2-dipyridin-2-ylethane-1,2-dione;Di-2-pyridylethanedione;1,2-di(pyridin-2-yl)ethane-1,2-dione;2,2-Pyridil;.alpha.-Pyridil;bis(pyridin-2-yl)ethane-1,2-dione;Ethanedione, di-2-pyridinyl-;Glyoxal, di-2-pyridyl-;Bis(2-pyridyl)ethanedione;CHEMBL373345;EINECS 207-759-9;AI3-52658;pyridil;NSC16545;2,2'-Dipyridil;MFCD00006301;2,2'-Pyridyl;starbld0019068;2,2'-Pyridil, 97%;SCHEMBL211487;1,2-Diketone, 2,2'-Pyridil;DTXSID90197711;1,2-diketone, 2,2''-pyridil;BDBM50171926;NSC 16545;NSC-16545;AKOS000119123;FG-0437;1,2-Di-pyridin-2-yl-ethane-1,2-dione;1,2-Di(2-pyridinyl)-1,2-ethanedione #;CS-0199434;FT-0632223;EN300-17335;E85318;10.14272/PIINXYKJQGMIOZ-UHFFFAOYSA-N.1;A827691;doi:10.14272/PIINXYKJQGMIOZ-UHFFFAOYSA-N.1

Chemical Property of 2,2'-Pyridil

Chemical Property:

• Melting Point: 154-156 °C
• Boiling Point: 400 °C at 760 mmHg
• PKA: 1.31±0.10(Predicted)
• Flash Point: 198.2 °C
• PSA: 59.92000
• Density: 1.271 g/cm³
• LogP: 1.54220
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 212.058577502
• Heavy Atom Count: 16
• Complexity: 250

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2′-Pyridil 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C(=O)C(=O)C2=CC=CC=N2

Technology Process of 2,2'-Pyridil

There total 14 articles about 2,2'-Pyridil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-hydroxy-1,2-di-2-pyridylethanone (1141-06-6) → 2,2'-Pyridil (492-73-9)

Guidance literature:

With hydrogenchloride; sodium hypobromide; In dichloromethane; water; at 25 ℃; for 5h;

DOI:10.1081/SCC-120001505

Reference yield: 90.0%

pyridine-2-carbaldehyde (1121-60-4) → 2,2'-Pyridil (492-73-9)

Guidance literature:

With oxygen; butyraldehyde; cobalt(II) chloride; In acetonitrile; Ambient temperature;

DOI:10.1016/S0040-4039(00)76671-8

Reference yield: 43.0%

pyridine-2-carbaldehyde (1121-60-4) → 2,2'-Pyridil (492-73-9) + 2-hydroxy-1,2-di-2-pyridylethanone (1141-06-6)

Guidance literature:

With C₁₅H₂₂N₃O₂⁽¹⁺⁾*Cl^(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.01.103

upstream raw materials:

pyridine-2-carbaldehyde

2-hydroxy-1,2-di-2-pyridylethanone

divinyl sulfoxide

6-formyl-2,2'-bipyridine

Downstream raw materials:

2,3-bis(2'-pyridyl)-5,6-dihydropyrazine

2,2'-dipyridyl ketone

2-hydroxy-1,2-di-2-pyridylethanone

2-Picolinic acid

Refernces

• 1、 Hirapara, Pradipbhai,Riemer, Daniel,Hazra, Nabanita,Gajera, Jignesh,Finger, Markus,Das, Shoubhik. "CO2-assisted synthesis of non-symmetric α-diketones directly from aldehydes: Via C-C bond formation". supporting information. p. 5356 - 5360. Retrieved 2017/11/22.
• 2、 Yu, Yangyang,Lin, Chenlu,Li, Bing,Zhao, Pengxiang,Zhang, Shiyong. "Dendrimer-like core cross-linked micelle stabilized ultra-small gold nanoclusters as a robust catalyst for aerobic oxidation of α-hydroxy ketones in water". . p. 3647 - 3655. Retrieved 2016/07/06.