1,3-BENZODIOXOL-5-YL(PHENYL)METHANONE

Base Information

• Chemical Name: 1,3-BENZODIOXOL-5-YL(PHENYL)METHANONE
• CAS No.: 54225-86-4
• Molecular Formula: C14H10O3
• Molecular Weight: 226.232
• Hs Code.: 2932999099
• Mol file: 54225-86-4.mol

Synonyms:1,3-benzodioxol-5-yl(phenyl)methanone;

Chemical Property of 1,3-BENZODIOXOL-5-YL(PHENYL)METHANONE

Chemical Property:

• Vapor Pressure: 6.63E-06mmHg at 25°C
• Melting Point: 56 °C
• Boiling Point: 377.7oC at 760 mmHg
• Flash Point: 173.7oC
• PSA: 35.53000
• Density: 1.265g/cm3
• LogP: 2.64630
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1,3-Benzodioxol-5-yl(phenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-BENZODIOXOL-5-YL(PHENYL)METHANONE

There total 57 articles about 1,3-BENZODIOXOL-5-YL(PHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Methylenedioxybenzene (274-09-9) + benzoic acid (65-85-0,8013-63-6) → (3,4-methylenedioxyphenyl) phenyl methanone (54225-86-4)

Guidance literature:

With trifluoroacetic acid; trifluoroacetic anhydride; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.01.026

Reference yield: 98.0%

tert-butyl benzoyl(tert-butoxycarbonyl)carbamate (135364-97-5) + 3,4-(methylenedioxy)-benzeneboronic acid (94839-07-3) → (3,4-methylenedioxyphenyl) phenyl methanone (54225-86-4)

Guidance literature:

With (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); potassium carbonate; In tetrahydrofuran; water; at 23 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b03191

Reference yield: 96.0%

trans-1-(3,4-methylenedioxyphenyl)-2-phenylethylene (51003-16-8,5426-80-2) → (3,4-methylenedioxyphenyl) phenyl methanone (54225-86-4)

Guidance literature:

With sodium periodate; tetraethylammonium iodide; In water; acetonitrile; at 105 ℃; for 12h; Sealed tube;

DOI:10.1039/c4ra08764j

upstream raw materials:

benzo[d][1,3]dioxol-5-yl(phenyl)methanimine

1,3-benzodioxol-5-yl(phenyl)methanol

Methylenedioxybenzene

benzoyl chloride

Downstream raw materials:

2-(benzo[d][1,3]dioxol-5-yl)-9-hydroxy-2-phenyl-4H-naphtho[2,3-d][1,3]dioxin-4-one

Refernces

• 1、 Du, Jihong,Duan, Baogen,Liu, Kun,Liu, Renhua,Yu, Feifei,Yuan, Yongkun,Zhang, Chenyang,Zhang, Jin. "Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water". supporting information. . Retrieved 2022/02/09.
• 2、 Heinz, Benjamin,Djukanovic, Dimitrije,Ganiek, Maximilian A.,Martin, Benjamin,Schenkel, Berthold,Knochel, Paul. "Selective Acylation of Aryl- A nd Heteroarylmagnesium Reagents with Esters in Continuous Flow". . p. 493 - 496. Retrieved 2020/01/31.