Technology Process of 6,8-Methanoquinolin-2(1H)-one, 5,6,7,8-tetrahydro-7,7-dimethyl-,
(6R,8R)-
There total 2 articles about 6,8-Methanoquinolin-2(1H)-one, 5,6,7,8-tetrahydro-7,7-dimethyl-,
(6R,8R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia;
In
methanol;
at 140 ℃;
for 15h;
under 9000.9 Torr;
Autoclave;
Inert atmosphere;
DOI:10.1016/j.tetasy.2013.03.004
- Guidance literature:
-
With
ammonium hydroxide;
In
methanol;
at 140 ℃;
for 10.5h;
under 11250.9 Torr;
DOI:10.1021/jo034179i
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 1.5 h / -78 °C / Inert atmosphere
2: triethylamine; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / methanol; N,N-dimethyl-formamide / 24 h / 80 °C / Schlenk technique; Inert atmosphere
3: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C
4: hydrogenchloride / ethanol / 12 h / 20 °C
With
hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; diisobutylaluminium hydride; triethylamine;
In
methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2013.03.004
