Azimilide dihydrochloride

Base Information

• Chemical Name: Azimilide dihydrochloride
• CAS No.: 149888-94-8
• Molecular Formula: C23H28 Cl N5 O3 . 2 Cl H
• Molecular Weight: 530.882
• European Community (EC) Number: 802-898-7
• UNII: 6E6VJP68KR
• Wikipedia: Azimilide
• NCI Thesaurus Code: C77977
• ChEMBL ID: CHEMBL3140370
• Mol file: 149888-94-8.mol

Synonyms:1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-2,4-imidazolidinedione dihydrochloride;2,4-Imidazolidinedione, 1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-, dihydrochloride;azimilide;azimilide dihydrochloride;azmilide;NE 10064;NE-10064

Chemical Property of Azimilide dihydrochloride

Chemical Property:

• Boiling Point: 594.9°Cat760mmHg
• Flash Point: 313.6°C
• PSA: 72.60000
• Density: 1.32g/cm³
• LogP: 4.58130
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble1mg/mL, clear (warmed)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 529.141423
• Heavy Atom Count: 34
• Complexity: 677

Purity/Quality:

99% ^*data from raw suppliers

Azimilide dihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)N=CC3=CC=C(O3)C4=CC=C(C=C4)Cl.Cl.Cl
• Isomeric SMILES: CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)/N=C/C3=CC=C(O3)C4=CC=C(C=C4)Cl.Cl.Cl
• Recent ClinicalTrials: Effect of Azimilide Dihydrochloride on Renal Function
• Recent EU Clinical Trials: A Phase 3 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Once-Daily Oral Doses of 75 mg Azimilide Dihydrochloride on the Incidence of Cardiovascular Hospitalizations/Emergency Department Visits or Cardiovascular Death in Patients with an Implantable Cardioverter Defibrillator
• Uses: Azimilide Dihydrochloride is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction. Azimilide dihydrochloride may be used in the electrophysiology experiments with human ether-a-go-go-related gene 1a (HERG1a) subunit.
• Therapeutic Function: Antiarrhythmic

Technology Process of Azimilide dihydrochloride

There total 3 articles about Azimilide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride hemi-hydrate → (E)-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride (149888-94-8)

Guidance literature:

In methanol; at 20 - 60 ℃; for 336 - 504h; Product distribution / selectivity;

Reference yield:

(E)-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride isopropanol solvate → (E)-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride (149888-94-8)

Guidance literature:

at 20 - 25 ℃; for 48h; Product distribution / selectivity;

Reference yield:

→ (E)-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride (149888-94-8)

Guidance literature:

In methanol; water; at 60 - 80 ℃; Purification / work up;

Refernces