Robenidine HCl; Cycostat; Chimcoccide

Base Information

• Chemical Name: Robenidine HCl; Cycostat; Chimcoccide
• CAS No.: 25875-50-7
• Molecular Formula: C15H14Cl3N5
• Molecular Weight: 370.669
• Mol file: 25875-50-7.mol

Synonyms:BCP25786;Robenidine HCl;Cycostat;Chimcoccide;PD056250;FT-0630518;Carbonimidic dihydrazide, N'',N'''-bis[(4-chlorophenyl)methylene]-, hydrochloride (1:1)

Chemical Property of Robenidine HCl; Cycostat; Chimcoccide

Chemical Property:

• Appearance/Colour: off-white solid
• Vapor Pressure: 1.12E-09mmHg at 25°C
• Melting Point: 252-254 °C
• Boiling Point: 475.8 °C at 760 mmHg
• Flash Point: 241.6 °C
• PSA: 72.63000
• LogP: 5.15890
• Storage Temp.: 0-6°C
• Solubility.: Robenidine hydrochloride possesses a weak solubility in water (<1 mg/L), but is soluble in organic solvents: 94 mg/L in dimethylsulfoxide, 46 mg/L in dimethylformamide, 20 mg/L in pyridine and 6.3 mg/L in ethanol (95%). The Log Kow is 3.3 (EFSA, 2004a).
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 369.031479
• Heavy Atom Count: 23
• Complexity: 408

Purity/Quality:

99% ^*data from raw suppliers

Robenidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=NNC(=NN=CC2=CC=C(C=C2)Cl)N)Cl.Cl
• Description: Robenidine hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.
• Uses: Robenidine hydrochloride is used as a coccidiostat for use in chickens for fattening and turkeys at a minimum-maximum concentration of 30-36 mg/kg complete feed, and in rabbits for fattening at a minimummaximum concentration of 50-66 mg/kg complete feed withdrawal period of 5 days for all target animals.

Technology Process of Robenidine HCl; Cycostat; Chimcoccide

There total 2 articles about Robenidine HCl; Cycostat; Chimcoccide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.82%

1,3-diaminoguanidine hydrochloride (36062-19-8,38360-74-6) + 4-chlorobenzaldehyde (104-88-1) → 2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride (25875-50-7)

Guidance literature:

With hydrogenchloride; In methanol; at 50 ℃; for 1h; pH=1.5; pH-value; Temperature;

Reference yield:

→ 2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride (25875-50-7)

Guidance literature:

Chlorbenzaldehyd, HCl, 1,3-Diaminoguanidinhydrochlorid;

Reference yield: 84.0%

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride (25875-50-7) + 2-(isocyanatomethyl)furan (71189-15-6) → 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-(furan-2-ylmethyl)hydrazine-1-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 2.5h; Reflux;

DOI:10.1021/acs.jmedchem.5b01797

upstream raw materials:

1,3-diaminoguanidine hydrochloride

4-chlorobenzaldehyde

Refernces

• 1、 Abraham, Rebecca J.,Stevens, Andrew J.,Young, Kelly A.,Russell, Cecilia,Qvist, Anastasia,Khazandi, Manouchehr,Wong, Hui San,Abraham, Sam,Ogunniyi, Abiodun D.,Page, Stephen W.,O'Handley, Ryan,McCluskey, Adam,Trott, Darren J.. "Robenidine Analogues as Gram-Positive Antibacterial Agents". . p. 2126 - 2138. Retrieved 2016/03/25.