2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride

Base Information

• Chemical Name: 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride
• CAS No.: 58911-02-7
• Molecular Formula: C11H12 N2 . Cl H
• Molecular Weight: 208.691
• Hs Code.: 2933990090
• European Community (EC) Number: 261-493-8
• DSSTox Substance ID: DTXSID60207659
• Mol file: 58911-02-7.mol

Synonyms:58911-02-7;2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride;Tetrahydronorharman;1,2,3,4-TETRAHYDRONORHARMANE HYDROCHLORIDE;EINECS 261-493-8;2,3,4,9-Tetrahydro-1H-pyrido(3,4-b)indole hydrochloride;1,2,3,4-Tetrahydro-9H-pyrido(3,4-b)indole hydrochloride;2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE HYDROCHLORIDE;2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;hydrochloride;9H-Pyrido(3,4-b)indole, 2,3,4,9-tetrahydro-, hydrochloride;1H,2H,3H,4H,9H-pyrido[3,4-b]indole hydrochloride;SCHEMBL8818317;DTXSID60207659;tetrahydro-b-carboline hydrochloride;MFCD00270566;AKOS024253360;AB05563;AS-30972;1,2,3,4-Tetrahydronorharmanehydrochloride;LS-133667;EN300-119677;A832070;Z1526503389;2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indolehydrochloride;1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-, monohydrochloride

Chemical Property of 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride

Chemical Property:

• Vapor Pressure: 4.05E-05mmHg at 25°C
• Melting Point: 282-284 °C
• Boiling Point: 351.6°C at 760 mmHg
• Flash Point: 166.5°C
• PSA: 27.82000
• LogP: 2.94440
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 208.0767261
• Heavy Atom Count: 14
• Complexity: 193

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,9-Tetrahydro-1H-b-carbolinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC2=C1C3=CC=CC=C3N2.Cl

Technology Process of 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride

There total 2 articles about 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3,4,9-Tetrahydro-2-(2-phenylmethyl)-1H-pyrido<3,4-b>indole hydrochloride (111357-86-9) → Tryptoline hydrochloride (58911-02-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 8h; under 2068.6 Torr; Ambient temperature;

DOI:10.1002/ardp.19873200106

Reference yield: 76.0%

ethanol (64-17-5) + 1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid (102991-38-8,6649-91-8) → Tryptoline hydrochloride (58911-02-7) + ethyl 1,2,3,4-tetrahydro-β-carboline-1-carboxylate hydrochloride

Guidance literature:

With thionyl chloride; for 4.5h;

DOI:10.1007/s007060200114

Reference yield: 95.0%

Tryptoline hydrochloride (58911-02-7) → betacarboline (244-63-3)

Guidance literature:

With 5 mol% Pd/C; lithium carbonate; In ethanol; at 150 ℃; for 1h; Sealed tube; Microwave irradiation;

DOI:10.1002/ejoc.201301580

upstream raw materials:

2,3,4,9-Tetrahydro-2-(2-phenylmethyl)-1H-pyrido<3,4-b>indole hydrochloride

ethanol

1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid

Downstream raw materials:

betacarboline

Refernces

• 1、 Lehmann,Ghoneim,El-Gendy. "Lactamisation of 4.9-dihydropyrano[3.4-b]indol-1(3H)-ones. A new synthetic route to the β-carboline ring system". . p. 30 - 36. Retrieved 2007/10/02.