N,N-DIMETHYLTRIFLUOROACETAMIDE

Base Information

• Chemical Name: N,N-DIMETHYLTRIFLUOROACETAMIDE
• CAS No.: 1547-87-1
• Molecular Formula: C4H6F3NO
• Molecular Weight: 141.093
• Hs Code.: 2924199090
• Mol file: 1547-87-1.mol

Synonyms:2,2,2-Trifluoro-N,N-dimethylacetamide;Dimethyltrifluoroacetamide;N,N-Dimethyltrifluoroacetamide;Trifluoro-N,N-dimethylacetamide;

Chemical Property of N,N-DIMETHYLTRIFLUOROACETAMIDE

Chemical Property:

• Vapor Pressure: 8.64mmHg at 25°C
• Refractive Index: 1.349
• Boiling Point: 133 °C at 760 mmHg
• PKA: -1?+-.0.70(Predicted)
• Flash Point: 36.7 °C
• PSA: 20.31000
• Density: 1.223 g/cm³
• LogP: 0.63690
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

N,N-Dimethyltrifluoroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIMETHYLTRIFLUOROACETAMIDE

There total 10 articles about N,N-DIMETHYLTRIFLUOROACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N-dimethylammonium chloride (506-59-2) + sodium 2,2,2-trifluoroacetate (2923-18-4) → N,N-dimethyl-2,2,2-trifluoroacetamide (1547-87-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetonitrile; at 20 ℃; for 0.5h; Green chemistry;

DOI:10.1039/d1ob02064a

Reference yield: 91.0%

ethyl trifluoroacetate, (383-63-1) + dimethyl amine (124-40-3) → N,N-dimethyl-2,2,2-trifluoroacetamide (1547-87-1)

Guidance literature:

for 16h; Ambient temperature;

DOI:10.1002/prac.199733901128

Reference yield: 47.2%

trifluoroacetic acid-methyl ester (431-47-0) + dimethyl amine (124-40-3) → N,N-dimethyl-2,2,2-trifluoroacetamide (1547-87-1)

Guidance literature:

upstream raw materials:

ethyl trifluoroacetate,

dimethyl amine

trifluoracetyl chloride

trifluoroacetic anhydride

Downstream raw materials:

2,2,2-trifluoro-1-(thiophen-2-yl)ethan-1-one

2,2,2-trifluoro-1-(thiophen-3-yl)ethan-1-one

1-(benzofuran-2-yl)-2,2,2-trifluoroethan-1-one

1-(benzo[b]thiophen-2-yl)-2,2,2-trifluoroethan-1-one

Refernces

• 1、 HSU. "". . p. 167,168, 177. Retrieved 1973.
• 2、 Ng. "". . p. 1586. Retrieved 1971.
• 3、 L Knunyants,I. et al.. "-". . . Retrieved 1966.
• 4、 LaPlanche Graham, Laurine. "Primary and Secondary Binding Sites for Lanthanide Shift Reagents with Amides. Differential Behavior of cis vs trans Amide Isomers with LSR". . p. 40 - 44. Retrieved 1980.
• 5、 Tormena, Claudio F.,Rittner, Roberto,Abraham, Raymond J.,Basso, Ernani A.,Pontes, Rodrigo M.. "Conformational analysis. Part 33. An NMR, solvation and theoretical investigation of conformational isomerism in N,N-dimethylfluoroacetamide and N,N-dimethyl-α-fluoropropionamide". . p. 2054 - 2059. Retrieved 2007/10/03.