6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

Base Information

• Chemical Name: 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide
• CAS No.: 60656-74-8
• Molecular Formula: C₁₅H₉Cl₂FN₂O
• Molecular Weight: 323.154
• Mol file: 60656-74-8.mol

Synonyms:6-Chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide;

Chemical Property of 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

Chemical Property:

• Melting Point: 154 - 158 °C
• PSA: 38.35000
• LogP: 4.86160
• Solubility.: Acetone, Chloroform, DCM

Purity/Quality:

6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline3-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide is an intermediate in the synthesis of the synthetic precursor of Midazolam (M343000), an anesthetic, anticonvulsant, sedative and hypotic agent.

Technology Process of 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

There total 1 articles about 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide (60656-74-8)

Guidance literature:

Dihydroverb.2b, MnO2;

Reference yield: 30.0%

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide (60656-74-8) + acetonitrile (75-05-8,26809-02-9) → 6-chloro-2-chloromethyl-4-(2-fluorophenyl)-1,2-dihydroquinazoline-2-acetonitrile 3-oxide (109774-09-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; warming from -50 deg C to room temperature;

DOI:10.1002/jhet.5570230509

Reference yield:

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide (60656-74-8) → 8-chloro-6-(2-fluorophenyl)-N,N-dimethyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide (109774-23-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) hexane, tetrahydrofuran, below -50 deg C 2) warming to room temperature, 1 h

2: PCl₃ / CH₂Cl₂ / 0.5 h

3: 70 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

4: 1) H₂, NH₃ / Raney nickel / 1) tetrahydrofuran, ethanol, methanol, atmospheric pressure, 5 h 2) reflux, 5 min

With ammonia; hydrogen; acetic acid; lithium diisopropyl amide; sodium nitrite; phosphorus trichloride; nickel; In dichloromethane;

DOI:10.1002/jhet.5570230509

Downstream raw materials:

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneaacetic acid t-butyl ester 4-oxide

<7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene>N,N-dimethylacetamide 4-oxide

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(methylsulfonyl)methylene>-1H-1,4-benzodiazepine 4-oxide