1-CHLOROPHTHALAZINE

Base Information

• Chemical Name: 1-CHLOROPHTHALAZINE
• CAS No.: 5784-45-2
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.594
• Hs Code.: 2933998090
• Mol file: 5784-45-2.mol

Synonyms:1-Chlorophthalazine;NSC 71104;

Chemical Property of 1-CHLOROPHTHALAZINE

Chemical Property:

• Appearance/Colour: Brown Solid
• Vapor Pressure: 4.43E-07mmHg at 25°C
• Melting Point: 109-112°C
• Refractive Index: 1.643
• Boiling Point: 364.3 °C at 760 mmHg
• PKA: 1.74±0.10(Predicted)
• Flash Point: 205.6 °C
• PSA: 25.78000
• Density: 1.349g/cm³
• LogP: 2.28320
• Storage Temp.: -20?C Freezer
• Sensitive.: Moisture Sensitive
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Insoluble in water. Soluble in dichloromethane, ethanol and methanol.

Purity/Quality:

99%, ^*data from raw suppliers

1-Chlorophthalazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Chlorophthalazine, is used as a pharmaceutical intermediate and are used as medical isotopes.

Technology Process of 1-CHLOROPHTHALAZINE

There total 6 articles about 1-CHLOROPHTHALAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phthalazone (119-39-1) → 1-chlorophthalazine (5784-45-2)

Guidance literature:

With trichlorophosphate; at 130 ℃; for 1.5h;

Reference yield: 73.0%

1-hydroxy-2,3-benzodiazine (119-39-1) → 1-chlorophthalazine (5784-45-2)

Guidance literature:

With trichlorophosphate; Reflux;

Reference yield:

PHTHALAZINE (253-52-1) → 1-chlorophthalazine (5784-45-2) + 1,4-dichlorophthalazine (4752-10-7)

Guidance literature:

With trichloroisocyanuric acid; In N,N-dimethyl-formamide; at 40 - 50 ℃;

DOI:10.1016/j.bmcl.2016.05.049

upstream raw materials:

phthalazone

trichlorophosphate

o-carboxybenzaldehyde

PHTHALAZINE

Downstream raw materials:

1-phenylphthalazine

2-((1H-indol-3-yl)methylene)-1-(phthalazin-4-yl)hydrazine

1-methoxyphthalazine

Refernces

• 1、 -. "BIS(HYDROXYMETHYL) PYRROLOPHTHALAZINE HYBRIDS, PREPARATION METHODS AND USES THEREOF". Page/Page column 0132-0135. . Retrieved 2019/06/09.
• 2、 -. "TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF". Page/Page column 64. . Retrieved 2019/05/22.