2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline

Base Information

• Chemical Name: 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline
• CAS No.: 39213-14-4
• Molecular Formula: C19H20N4O
• Molecular Weight: 320.3883
• Mol file: 39213-14-4.mol

Synonyms:2-(4-methyl-piperazin-1-yl)-4-phenoxy-quinazoline;2-(4-Methyl-1-piperazinyl)-4-phenoxyquinazoline;Quinazoline,2-(4-methyl-1-piperazinyl)-4-phenoxy;2-(N-Methylpiperazino)-4-phenoxy-chinazolin;2-(4-methylpiperazinyl)-4-phenoxyquinazoline;

Chemical Property of 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline

Chemical Property:

• Vapor Pressure: 3.4E-10mmHg at 25°C
• Boiling Point: 501.7°Cat760mmHg
• Flash Point: 257.2°C
• PSA: 41.49000
• Density: 1.214g/cm³
• LogP: 3.17680

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline

There total 6 articles about 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Chloro-2-(4-methyl-1-piperazinyl)quinazoline (39213-06-4) + phenol (108-95-2,27073-41-2) → 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline (39213-14-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1248/cpb.38.681

Reference yield:

1-methyl-piperazine (109-01-3) + 2-chloro-4-phenoxyquinazoline (858027-20-0) → 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline (39213-14-4)

Guidance literature:

at 140 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/jm800876b

Reference yield:

1-methyl-piperazine (109-01-3) → 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline (39213-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / 155 - 160 °C

2: 88 percent / POCl₃ / 130 °C

3: 70 percent / 60percent NaH / dimethylformamide / 60 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.681

upstream raw materials:

4-Chloro-2-(4-methyl-1-piperazinyl)quinazoline

phenol

1-methyl-piperazine

2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one

Refernces

• 1、 Smits, Rogier A.,De Esch, Iwan J. P.,Zuiderveld, Obbe P.,Broeker, Joachim,Sansuk, Kamonchanok,Guaita, Elena,Coruzzi, Gabriella,Adami, Maristella,Haaksma, Eric,Leurs, Rob. "Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach". experimental part. p. 7855 - 7865. Retrieved 2009/12/07.