MELANOXETIN

Base Information

• Chemical Name: MELANOXETIN
• CAS No.: 489-58-7
• Molecular Formula: C15H10 O7
• Molecular Weight: 302.24
• Mol file: 489-58-7.mol

Synonyms:Flavone,3,3',4',7,8-pentahydroxy- (6CI,8CI); Melanoxetin (7CI);3,7,8,3',4'-Pentahydroxyflavone; 3',4',7,8-Tetrahydroxyflavonol

Chemical Property of MELANOXETIN

Chemical Property:

• PSA: 131.36000
• LogP: 1.98800

Purity/Quality:

99% ^*data from raw suppliers

3,7,8,3',4'-Pentahydroxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,7,8,3'',4''-Pentahydroxyflavone is used for Xanthine Oxidase inhibition for gout treatment by decreasing Uric Acid levels and free radical formation.

Technology Process of MELANOXETIN

There total 6 articles about MELANOXETIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-[3,4-bis(benzyloxy)phenyl]-3-hydroxy-7,8-dimethoxy-4H-chromen-4-one → melanoxetin (489-58-7)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.04.057

Reference yield:

2'-hydroxy-3',4'-dimethoxyacetophenone (5396-18-9) → melanoxetin (489-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 72 h / Reflux

2: sodium hydroxide; dihydrogen peroxide / methanol; water; tetrahydrofuran / 0 - 20 °C

3: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / Inert atmosphere

With dihydrogen peroxide; boron tribromide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1: |Aldol Condensation;

DOI:10.1016/j.ejmech.2016.04.057

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → melanoxetin (489-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 72 h / Reflux

2: sodium hydroxide; dihydrogen peroxide / methanol; water; tetrahydrofuran / 0 - 20 °C

3: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / Inert atmosphere

With dihydrogen peroxide; boron tribromide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1: |Aldol Condensation;

DOI:10.1016/j.ejmech.2016.04.057

upstream raw materials:

1,2,3,4-tetramethoxybenzene

2'-hydroxy-3',4'-dimethoxyacetophenone

3,4-dibenzyloxybenzaldehyde

Downstream raw materials:

2-(3,4-dimethoxy-phenyl)-3-hydroxy-7,8-dimethoxy-chromen-4-one

2-(3,4-dimethoxy-phenyl)-3,7,8-trimethoxy-chromen-4-one

Refernces