Ethyl L-serinate hydrochloride

Base Information

• Chemical Name: Ethyl L-serinate hydrochloride
• CAS No.: 26348-61-8
• Molecular Formula: C5H11NO3^.HCl
• Molecular Weight: 169.608
• Hs Code.: 29225090
• European Community (EC) Number: 247-624-1
• DSSTox Substance ID: DTXSID40180951
• Mol file: 26348-61-8.mol

Synonyms:26348-61-8;L-Serine ethyl ester hydrochloride;H-Ser-OEt.HCl;Ethyl L-serinate hydrochloride;(S)-Ethyl 2-amino-3-hydroxypropanoate hydrochloride;L-Serine ethyl ester HCl;L-Serine ethyl ester, HCl;serine ethyl ester hydrochloride;L-Serine, ethyl ester, hydrochloride;ethyl (2S)-2-amino-3-hydroxypropanoate hydrochloride;ethyl (2S)-2-amino-3-hydroxypropanoate;hydrochloride;MFCD00012594;Ethyl L-serinate HCl;EINECS 247-624-1;H-Ser-OEt HCl;H-Ser-OEt. HCl;L-Serine, ethyl ester, hydrochloride (1:1);C5H11NO3.ClH;SCHEMBL593290;L-serine ethylester hydrochloride;DTXSID40180951;ethyl serinate, hydrochloride salt;JZJQCLZQSHLSFB-WCCKRBBISA-N;FD3052;AKOS015894547;AKOS015924170;AM82215;CS-W017712;HY-W016996;BP-12469;DS-15105;(S)-Ethyl 2-amino-3-hydroxypropanoate HCl;EN300-6474410;L-Serine ethyl ester hydrochloride, 99% (TLC);A818400;ethyl(2s)-2-amino-3-hydroxypropanoate hydrochloride;J-300254;Q-101606;ethyl (2S)-2-amino-3-hydroxypropanoate,hydrochloride

Chemical Property of Ethyl L-serinate hydrochloride

Chemical Property:

• Appearance/Colour: white to beige needle-like crystalline powder
• Vapor Pressure: 0.00407mmHg at 25°C
• Melting Point: 130-132 °C(lit.)
• Boiling Point: 247.9 °C at 760 mmHg
• Flash Point: 103.7 °C
• PSA: 72.55000
• LogP: 0.37140
• Storage Temp.: 0-6°C
• Sensitive.: Hygroscopic
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 169.0505709
• Heavy Atom Count: 10
• Complexity: 94.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Serine ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)C(CO)N.Cl
• Isomeric SMILES: CCOC(=O)[C@H](CO)N.Cl

Technology Process of Ethyl L-serinate hydrochloride

There total 6 articles about Ethyl L-serinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + L-serin (56-45-1,83245-15-2) → L-serine ethyl ester hydrochloride (26348-61-8,104055-46-1)

Guidance literature:

With thionyl chloride; at 0 ℃; Inert atmosphere;

Reference yield: 87.0%

ethyl chlorosulfite (6378-11-6) + L-serin (56-45-1,83245-15-2) → L-serine ethyl ester hydrochloride (26348-61-8,104055-46-1)

Guidance literature:

at -5 - 60 ℃; for 4h;

DOI:10.1002/cbdv.201800059

Reference yield: 84.0%

(S)-ethyl N-trifluoroacetyl-O-(m-chlorobenzoyl)serinate (81852-20-2) → L-serine ethyl ester hydrochloride (26348-61-8,104055-46-1)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

upstream raw materials:

ethanol

L-serin

(S)-ethyl N-trifluoroacetyl-O-(m-chlorobenzoyl)serinate

acid chloride of (2S)-α-ethyl N-trifluoroacetylaspartate

Downstream raw materials:

N-arachidonoyl serine

C₂₄H₃₃NO₅Si

ethyl L-serinate

Refernces

• 1、 -. "Method for preparing Fmoc-Ser (tBu)-OH". Paragraph 0061-0062. . Retrieved 2020/12/30.
• 2、 -. "OLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID OLEIC ACID DERIVATIVES, AND THEIR USES". Page/Page column 35-36. . Retrieved 2019/12/25.