Tremorine

Base Information

• Chemical Name: Tremorine
• CAS No.: 51-73-0
• Molecular Formula: C12H20 N2
• Molecular Weight: 192.304
• Hs Code.: 2933990090
• NSC Number: 407428
• UNII: U817VZ1URQ
• DSSTox Substance ID: DTXSID00199004
• Nikkaji Number: J4.126B
• Wikipedia: Tremorine
• Wikidata: Q7838182
• ChEMBL ID: CHEMBL1483237
• Mol file: 51-73-0.mol

Synonyms:Tremorine

Chemical Property of Tremorine

Chemical Property:

• Melting Point: 25°C
• Refractive Index: 1.5200 (estimate)
• Boiling Point: 285.6°Cat760mmHg
• Flash Point: 118.4°C
• PSA: 6.48000
• Density: 1.014g/cm³
• LogP: 1.05720
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 192.162648646
• Heavy Atom Count: 14
• Complexity: 201

Purity/Quality:

99% ^*data from raw suppliers

1,1'-(2-BUTYNYLENE)DIPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)CC#CCN2CCCC2

Technology Process of Tremorine

There total 6 articles about Tremorine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

pyrrolidine (123-75-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + calcium carbide (75-20-7) → 1,4-di(pyrrolidin-1-yl)but-2-yne (51-73-0)

Guidance literature:

With water; copper(l) chloride; In dimethyl sulfoxide; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.3184/174751917X14949427622099

Reference yield:

pyrrolidine (123-75-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + acetylene (74-86-2,25067-58-7) → 1,4-di(pyrrolidin-1-yl)but-2-yne (51-73-0)

Guidance literature:

With copper(l) chloride;

DOI:10.1021/ja01572a045

Reference yield:

pyrrolidine (123-75-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + trimethylsilylacetylene (1066-54-2) → 1,4-di(pyrrolidin-1-yl)but-2-yne (51-73-0)

Guidance literature:

With Echavarren's catalyst; In ethanol; water; at 50 ℃; for 2h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1002/chem.201605269

upstream raw materials:

pyrrolidine

1,4-Dichloro-2-butyne

formaldehyd

acetylene

Downstream raw materials:

1c,4t-dipyrrolidino-buta-1,3-diene

2,5-dipyrrolidino-adiponitrile

1,1'-dimethyl-1,1'-but-2-ynediyl-bis-pyrrolidinium; diiodide

Refernces

• 1、 Fu, Rugang,Li, Zheng. "N-Propargylation of secondary amines directly using calcium carbide as an acetylene source". . p. 341 - 345. Retrieved 2017/06/19.