4-NITROPHENYLACETONE

Base Information

• Chemical Name: 4-NITROPHENYLACETONE
• CAS No.: 5332-96-7
• Molecular Formula: C9H9 N O3
• Molecular Weight: 179.175
• Hs Code.: 2914700090
• Mol file: 5332-96-7.mol

Synonyms:2-Propanone,(p-nitrophenyl)- (7CI); 2-Propanone, 1-(p-nitrophenyl)- (8CI);(p-Nitrophenyl)acetone; 1-(4-Nitrophenyl)acetone; 1-(4-Nitrophenyl)propan-2-one;1-(p-Nitrophenyl)-2-propanone; 4-Nitrophenylacetone; Methyl 4-nitrobenzylketone; NSC 581

Chemical Property of 4-NITROPHENYLACETONE

Chemical Property:

• Vapor Pressure: 0.000724mmHg at 25°C
• Melting Point: 63-64°C
• Boiling Point: 307.5°Cat760mmHg
• Flash Point: 146.4°C
• PSA: 62.89000
• Density: 1.212g/cm³
• LogP: 2.24950
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water, soluble in usual organic solvents.

Purity/Quality:

99%, ^*data from raw suppliers

1-(4-Nitrophenyl)propan-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 23-36/37/39

MSDS Files:

Useful:

• Uses: It is applied as an intermediate in organic synthesis.

Technology Process of 4-NITROPHENYLACETONE

There total 53 articles about 4-NITROPHENYLACETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

4-nitrobenzeneacetic acid (104-03-0) + acetic anhydride (108-24-7) → 1-(4-nitrophenyl)propan-2-one (5332-96-7)

Guidance literature:

4-nitrobenzeneacetic acid; acetic anhydride; With acetic acid; for 2h; Inert atmosphere; Large scale;

With 1-methyl-1H-imidazole; at 30 - 35 ℃; for 24h; Inert atmosphere; Large scale;

Reference yield: 92.0%

Isopropenyl acetate (108-22-5) + 4-nitrobenzenediazonium tetrafluoroborate (456-27-9) → 1-(4-nitrophenyl)propan-2-one (5332-96-7)

Guidance literature:

With UiO-66 nanoparticles constructed by zirconium cations and terephthalate; In water; at 20 ℃; for 12h; Solvent; Reagent/catalyst; Catalytic behavior;

DOI:10.1002/aoc.5482

Reference yield: 89.0%

Isopropenyl acetate (108-22-5) + 4-nitro-aniline (100-01-6,104810-17-5) → 1-(4-nitrophenyl)propan-2-one (5332-96-7)

Guidance literature:

With tert.-butylnitrite; eosin bluish; In water; at 20 ℃; for 2h; Sealed tube; Irradiation; Micellar solution; Green chemistry;

DOI:10.1039/c8cy01221k

upstream raw materials:

diazomethane

p-nitrophenylacetaldehyde

4-nitrobenzaldehdye

2-acetoxy-1-(4-nitro-phenyl)-propene

Downstream raw materials:

(p-nitrophenyl)acetone ethylene glycol ketal

(+/-)1-[1-methyl-2-(4-nitrophenyl)ethyl]-4-phenylpiperazine

2-[1-methyl-3-(4-nitrophenyl)-4-oxo-2-pentenylidene]-1-hydrazinecarboxamide

C₁₉H₁₆N₂O₅S

Refernces

• 1、 Albarrán-Velo, Jesús,Gotor-Fernández, Vicente,Lavandera, Iván. "Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols". . p. 4096 - 4108. Retrieved 2021/08/19.
• 2、 Sun, Zhong-Hua,Chen, Wang,Qian, Bing-Bing,Wang, Liang,Yu, Binxun,Chen, Qun,He, Ming-Yang,Zhang, Zhi-Hui. "UiO-66 microcrystals catalyzed direct arylation of enol acetates and heteroarenes with aryl diazonium salts in water". . . Retrieved 2020/01/25.