8-AMINOGUANOSINE

Base Information

• Chemical Name: 8-AMINOGUANOSINE
• CAS No.: 3868-32-4
• Molecular Formula: C10H14N6O5
• Molecular Weight: 298.258
• Hs Code.: 29389090
• Mol file: 3868-32-4.mol

Synonyms:Inosine,2,8-diamino- (7CI,8CI);NSC 90390;8-Aminoguanosine;

Chemical Property of 8-AMINOGUANOSINE

Chemical Property:

• Appearance/Colour: Off-White to Tan Solid
• Vapor Pressure: 1.85E-27mmHg at 25°C
• Melting Point: 261°C dec.
• Refractive Index: 2.04
• Boiling Point: 806.4 °C at 760 mmHg
• Flash Point: 441.5 °C
• PSA: 185.53000
• Density: 2.44 g/cm³
• LogP: -1.94210
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated), H

Purity/Quality:

99%, ^*data from raw suppliers

8-Aminoguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A potent inhibitor of purine nucleoside phosphorylase

Technology Process of 8-AMINOGUANOSINE

There total 4 articles about 8-AMINOGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-nitroguanosine → 8-aminoguanosine (3868-32-4) + C8:5'-O-cyclo-Guo (74227-98-8) + G (118-00-3)

Guidance literature:

With sodium tetrahydroborate; In water; for 1.5h;

DOI:10.1002/chem.201705541

Reference yield:

8-nitroguanosine → 8-aminoguanosine (3868-32-4) + 8-mercapto-guanosine (26001-38-7)

Guidance literature:

With diethylenetriaminopentaacetic acid; hydrogen sulfide; In aq. buffer; at 37 ℃; for 3h; pH=7.1;

DOI:10.1039/c4ob00868e

Reference yield:

DL-Penicillamin (52-66-4) + 8-nitroguanosine → 8-aminoguanosine (3868-32-4) + C13H18N6O7S + 8-mercapto-guanosine (26001-38-7)

Guidance literature:

With diethylenetriaminopentaacetic acid; hydrogen sulfide; In aq. buffer; at 37 ℃; for 3h; pH=7.1;

DOI:10.1039/c4ob00868e

upstream raw materials:

N⁷-aminoguanosine

DL-Penicillamin

Downstream raw materials:

8-aminoguanine

Refernces

• 1、 Terzic,Padovani,Balland,Artaud,Galardon. "Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur". . p. 5360 - 5364. Retrieved 2014/07/21.