2-(Methylsulfonyl)isonicotinonitrile

Base Information

• Chemical Name: 2-(Methylsulfonyl)isonicotinonitrile
• CAS No.: 66154-69-6
• Molecular Formula: C₇H₆N₂O₂S
• Molecular Weight: 182.203
• Hs Code.: 2933399990
• Mol file: 66154-69-6.mol

Synonyms:2-(methanesulfonyl)-4-cyanopyridine;2-Methanesulfonyl-isonicotinonitrile;2-(methylsulfonyl)isonicotinonitrile;

Chemical Property of 2-(Methylsulfonyl)isonicotinonitrile

Chemical Property:

• Melting Point: 144 - 145 °C (methanol)
• Boiling Point: 396.8±42.0 °C(Predicted)
• PKA: -4.99±0.20(Predicted)
• PSA: 79.20000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 1.43758

Purity/Quality:

99% ^*data from raw suppliers

2-Methanesulfonylpyridine-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Methylsulfonyl)isonicotinonitrile

There total 3 articles about 2-(Methylsulfonyl)isonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-chloro-4-pyridinenitrile (33252-30-1) + sodium methansulfinate (20277-69-4) → 4‐cyano‐2‐methylsulfonylpyridine (66154-69-6)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 125 ℃; for 14h;

DOI:10.1002/jlcr.3635

Reference yield: 58.0%

2-chloro-4-pyridinenitrile (33252-30-1) + sodium thiomethoxide (5188-07-8) → 4‐cyano‐2‐methylsulfonylpyridine (66154-69-6)

Guidance literature:

2-chloro-4-pyridinenitrile; sodium thiomethoxide; In tetrahydrofuran; at 50 ℃; for 2h;

With sodium perborate tetrahydrate; acetic acid; In tetrahydrofuran; at 55 ℃; for 16h;

Reference yield:

→ 4‐cyano‐2‐methylsulfonylpyridine (66154-69-6)

Guidance literature:

/BRN= 111968/, CH3SO2Cl, KCN, Acn., H2O;

upstream raw materials:

2-chloro-4-pyridinenitrile

sodium thiomethoxide

sodium methansulfinate

Refernces

• 1、 -. "AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS". Page/Page column 169. . Retrieved 2010/04/27.