Bis-(dimethylaminopropyl)amine

Base Information

• Chemical Name: Bis-(dimethylaminopropyl)amine
• CAS No.: 6711-48-4
• Deprecated CAS: 86003-72-7,1467059-84-2,136363-31-0
• Molecular Formula: C10H25 N3
• Molecular Weight: 187.329
• Hs Code.: 2921290000
• European Community (EC) Number: 229-761-9
• NSC Number: 129937
• UNII: CW8R6R660G
• DSSTox Substance ID: DTXSID7044974
• Nikkaji Number: J26.193I
• Wikidata: Q27275858
• ChEMBL ID: CHEMBL28766
• Mol file: 6711-48-4.mol

Synonyms:tetramethyldipropylenetriamine;TMDPT

Chemical Property of Bis-(dimethylaminopropyl)amine

Chemical Property:

• Vapor Pressure: 30Pa at 20℃
• Melting Point: −78°C(lit.)
• Refractive Index: n20/D 1.449(lit.)
• Boiling Point: 128-131°C20mmHg(lit.)
• PKA: 10.40±0.19(Predicted)
• Flash Point: 209°F
• PSA: 18.51000
• Density: 0.841g/mLat25°C(lit.)
• LogP: 0.87030
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: 425g/L at 20℃
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 187.204847810
• Heavy Atom Count: 13
• Complexity: 90.3

Purity/Quality:

99% ^*data from raw suppliers

3,3''-Iminobis(N,N-dimethylpropylamine) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 21/22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCCNCCCN(C)C
• Uses: 3,3'-Iminobis(N,N-dimethylpropylamine) is used as a reagent in the synthesis of a novel class of anticancer agents called antracenylisoxazole lexitropsin conjugates. 3,3'-Iminobis(N,N-dimethylpropylamine) is also part of a group of stabilizers (Hindered Amino Stabilizers) that prevent the thermo-oxidative degradation of polypropylene. 3,3′-Iminobis(N,N-dimethylpropylamine) may be used:in the synthesis of dimeric quaternary alkylammonium conjugates of sterolsas nitrogen containing tridentate lignand in the preparation of [3,3′-iminobis(N,N-dimethylpropylamine)](4′-methoxyflavonolato)zinc(II) perchlorate complexin the preparation of 2-[[[N,N-bis[3-(N,N-dimethylamino)propyl]amino]carbonyl]-1-methyl-4-nitropyrrole and 3-(9-anthracenyl)- N,N-bis[3-(N,N-dimethylamino)propyl]-5-methyl-4-isoxazole carboxamide

Technology Process of Bis-(dimethylaminopropyl)amine

There total 12 articles about Bis-(dimethylaminopropyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.98%

α-(dimethylamino)-propionitrile (5350-67-4) → propylamine (107-10-8,42939-71-9) + N,N,N'N'-tetramethyl-1,3-propanediamine (110-95-2) + 1-amino-3-(dimethylamino)propane (109-55-7) + N,N-bis-(3-dimethylaminopropyl)amine (6711-48-4,86003-72-7)

Guidance literature:

With caustic; hydrogen; nickel catalyst Degussa MC₅₀₂; In water; at 90 ℃; for 0.45h; under 5932.2 Torr; Product distribution / selectivity;

Reference yield: 75.6%

1-amino-3-(dimethylamino)propane (109-55-7) + 3-dimethylaminopropiononitrile (1738-25-6) → N,N-bis-(3-dimethylaminopropyl)amine (6711-48-4,86003-72-7)

Guidance literature:

With Cu-Cr2O3-CoO/γ-Al2O3; hydrogen; In toluene; at 100 ℃; under 7500.75 Torr; Reagent/catalyst;

DOI:10.1016/j.catcom.2018.03.031

Reference yield:

α-(dimethylamino)-propionitrile (5350-67-4) → 1-amino-3-(dimethylamino)propane (109-55-7) + N,N-bis-(3-dimethylaminopropyl)amine (6711-48-4,86003-72-7)

Guidance literature:

With sodium hydroxide; hydrogen; nickel catalyst Degussa MC₅₀₂; In water; at 90 ℃; under 5688.78 Torr; Product distribution / selectivity;

upstream raw materials:

N,N-bis-(3-dimethylamino-propyl)-benzenesulfonamide

3-dimethylaminopropiononitrile

butan-1-ol

3-(Dimethylamino)propyl chloride

Downstream raw materials:

N,N-bis-(3-dimethylamino-propyl)-benzenesulfonamide

N'-[3-(dimethylamino)propyl]-N,N,N'-trimethylpropane-1,3-diamine

Zn(II) 4'-chloroflavonolate (3,3'-iminobis(N,N-dimethylpropylamine)) perchlorate

Zn(II) 4'-methylflavonolate (3,3'-iminobis(N,N-dimethylpropylamine)) perchlorate

Refernces

• 1、 -. "Synthesis method of tetramethyl diene triamine compound". Paragraph 0015-0021. . Retrieved 2020/07/06.
• 2、 -. "METHOD FOR PRODUCING BIS-[(3-DIMETHYLAMINO)PROPYL]AMINE (BISDMAPA)". Page/Page column 3; 9. . Retrieved 2008/06/13.