4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one

Base Information Edit

Chemical Name:4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
CAS No.:674-26-0
Deprecated CAS:503-48-0
Molecular Formula:C6H10 O3
Molecular Weight:130.144
Hs Code.:2932999099
European Community (EC) Number:433-160-9,211-615-0
NSC Number:90804
UNII:1RJ06DC41B
DSSTox Substance ID:DTXSID00964572
Nikkaji Number:J38.600F
Wikidata:Q27166894
Metabolomics Workbench ID:4337
ChEMBL ID:CHEMBL4758470
Mol file:674-26-0.mol

Synonyms:mevalonic acid lactone;mevalonolactone;mevalonolactone, (+-)-isomer;mevalonolactone, (R)-isomer;mevalonolactone, (S)-isomer;mevalonolactone, 3-(14)C-labeled

Suppliers and Price of 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
D,L-MevalonicAcidLactone
2.5g
$ 305.00

TCI Chemical
DL-Mevalonolactone >98.0%(GC)
100mg
$ 72.00

Sigma-Aldrich
(±)-Mevalonolactone ~97% (titration)
1g
$ 172.00

Sigma-Aldrich
(±)-Mevalonolactone ~97% (titration)
10g
$ 741.00

Sigma-Aldrich
(±)-Mevalonolactone ~97% (titration)
5g
$ 536.00

Medical Isotopes, Inc.
(+/-)-Mevalonolactone
1 g
$ 490.00

ChemScene
DL-Mevalonolactone >98.0%
100mg
$ 230.00

ChemScene
DL-Mevalonolactone >98.0%
50mg
$ 135.00

ChemScene
DL-Mevalonolactone >98.0%
10mg
$ 120.00

Chem-Impex
(±)-Mevalonolactone,98%(GC) 98%(GC)
1G
$ 89.60

Total 63 raw suppliers

Chemical Property of 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one Edit

Chemical Property:

Appearance/Colour:Moist pale yellow to off white solid
Vapor Pressure:0.000662mmHg at 25°C
Melting Point:28 °C(lit.)
Refractive Index:n20/D 1.473(lit.)
Boiling Point:145-150 °C5 mm Hg(lit.)
PKA:13.57±0.20(Predicted)
Flash Point:>230 °F
PSA：46.53000
Density:1.189 g/cm³
LogP:0.07440
Storage Temp.:2-8°C
Solubility.:Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:130.062994177
Heavy Atom Count:9
Complexity:132

Purity/Quality:

98% ^*data from raw suppliers

D,L-MevalonicAcidLactone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1(CCOC(=O)C1)O
Description DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
Uses A metabolite from endophytes of the medicinal plant Erythrina crista-galli. HMG CoA substrate (±)-Mevalonolactone is used to:study the effect of statin on the prenylation of Ras and Rho GTPasesanalyse the isoprenoid biosynthesis pathways in Listeria monocytogenesstudy the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)

Technology Process of 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one

There total 45 articles about 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%