Methanetricarboxylic acid, [(1R)-2,3-dihydro-1H-inden-1-yl]-, triethyl ester

Base Information

• Chemical Name: Methanetricarboxylic acid, [(1R)-2,3-dihydro-1H-inden-1-yl]-, triethyl ester
• CAS No.: 666824-82-4
• Molecular Formula: C19H24O6
• Molecular Weight: 348.396
• Mol file: 666824-82-4.mol

Synonyms:

Chemical Property of Methanetricarboxylic acid, [(1R)-2,3-dihydro-1H-inden-1-yl]-, triethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanetricarboxylic acid, [(1R)-2,3-dihydro-1H-inden-1-yl]-, triethyl ester

There total 2 articles about Methanetricarboxylic acid, [(1R)-2,3-dihydro-1H-inden-1-yl]-, triethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanetricarboxylic acid triethyl ester (6279-86-3) + (S)-indanol (25501-32-0) → triethyl (1R)-2,3-dihydro-1H-inden-1-ylmethanetricarboxylate (666824-82-4)

Guidance literature:

With diethylazodicarboxylate; trimethylphosphane; In toluene; at -53 - 20 ℃;

DOI:10.1021/ol036380l

Reference yield: 71.0%

methanetricarboxylic acid triethyl ester (6279-86-3) + (S)-indanol (25501-32-0) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → triethyl (1R)-2,3-dihydro-1H-inden-1-ylmethanetricarboxylate (666824-82-4)

Guidance literature:

(S)-indanol; chloro-diphenylphosphine; With dmap; triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

methanetricarboxylic acid triethyl ester; With diethylazodicarboxylate; In tetrahydrofuran; toluene; at -63 - 20 ℃;

DOI:10.1246/cl.2005.1676

upstream raw materials:

methanetricarboxylic acid triethyl ester

(S)-indanol

chloro-diphenylphosphine

Refernces

• 1、 Hillier, Michael C.,Desrosiers, Jean-Nicolas,Marcoux, Jean-Francois,Grabowski, Edward J. J.. "Stereoselective Carbon-Carbon Bond Formation via the Mitsunobu Displacement of Chiral Secondary Benzylic Alcohols". . p. 573 - 576. Retrieved 2007/10/03.