3-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE
• CAS No.: 667461-63-4
• Molecular Formula: C12H14F3N
• Molecular Weight: 229.245
• Mol file: 667461-63-4.mol

Synonyms:

Chemical Property of 3-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• LogP: 3.50120

Purity/Quality:

95-99% ^*data from raw suppliers

3-(4-(Trifluoromethyl)phenyl)piperidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE

There total 5 articles about 3-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 3-(4-(trifluoromethyl)phenyl)piperidine-1-carboxylate → 3-[4-(trifluoromethyl)phenyl]piperidine (667461-63-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

tert-butyl 3-(4-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-carboxylate → 3-[4-(trifluoromethyl)phenyl]piperidine (667461-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

5-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (180691-65-0) → 3-[4-(trifluoromethyl)phenyl]piperidine (667461-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane / 8 h / 105 °C / Inert atmosphere

2: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; hydrogen; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane;

upstream raw materials:

5-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

p-trifluoromethylphenyl bromide

5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE". . . Retrieved 2020/02/06.