2,4-Dimethylquinazoline

Base Information

• Chemical Name: 2,4-Dimethylquinazoline
• CAS No.: 703-63-9
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Hs Code.: 2933990090
• Mol file: 703-63-9.mol

Synonyms:Quinazoline, 2,4-dimethyl-;

Chemical Property of 2,4-Dimethylquinazoline

Chemical Property:

• Vapor Pressure: 0.399mmHg at 25°C
• Melting Point: 70 °C
• Refractive Index: 1.617
• Boiling Point: 203.3 °C at 760 mmHg
• PKA: 4.46±0.50(Predicted)
• Flash Point: 61.9 °C
• PSA: 25.78000
• Density: 1.109 g/cm³
• LogP: 2.24660
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dimethylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dimethylquinazoline

There total 1 articles about 2,4-Dimethylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-aminophenyl)ethanone O-phenyl oxime (1044742-98-4) + acetone (67-64-1) → 2,4-dimethylquinoline (1198-37-4) + 2-(2'-aminophenyl)-4-methylquinoline (6637-33-8) + 2,2,4-trimethyl-1,2-dihydroquinazoline (1160304-74-4) + 2,4-dimethylquinazoline (703-63-9) + 2-aminoacetophenone (551-93-9) + 2-(4-methylquinazolin-2-yl)aniline (16115-46-1)

Guidance literature:

With zinc(II) chloride; In toluene; at 160 ℃; for 0.5h; Microwave irradiation; Ionic liquid;

DOI:10.1021/jo900629g

Reference yield: 79.0%

bromochlorobenzene (106-39-8) + 2,4-dimethylquinazoline (703-63-9) → (4-chlorophenyl)(2-methylquinazolin-4-yl)methanone (140640-34-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 24h;

DOI:10.1039/c3ob41488d

Reference yield: 76.0%

bromobenzene (108-86-1,52753-63-6) + 2,4-dimethylquinazoline (703-63-9) → (2-methylquinazolin-4-yl)(phenyl)methanone (101290-94-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 24h;

DOI:10.1039/c3ob41488d

upstream raw materials:

1-(2-aminophenyl)ethanone O-phenyl oxime

acetone

Downstream raw materials:

2-methyl-6-nitroquinazolin-4(3H)-one

2-methyl-4-quinazolone

(4-methoxyphenyl)(2-methylquinazolin-4-yl)methanone

(4-chlorophenyl)(2-methylquinazolin-4-yl)methanone

Refernces