2,4-difluoro-1,3,5-trimethylbenzene

Base Information

• Chemical Name: 2,4-difluoro-1,3,5-trimethylbenzene
• CAS No.: 392-61-0
• Molecular Formula: C9H10 F2
• Molecular Weight: 156.1725
• Mol file: 392-61-0.mol

Synonyms:Mesitylene,2,4-difluoro- (8CI); 2,4-Difluoro-1,3,5-trimethylbenzene;2,4-Difluoromesitylene; NSC 10358

Chemical Property of 2,4-difluoro-1,3,5-trimethylbenzene

Chemical Property:

• Vapor Pressure: 2.3mmHg at 25°C
• Boiling Point: 166.9°Cat760mmHg
• Flash Point: 42.4°C
• Density: 1.064g/cm³

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-difluoro-1,3,5-trimethylbenzene

There total 5 articles about 2,4-difluoro-1,3,5-trimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1,3,5-trimethyl-benzene (108-67-8) → 1,3-difluoro-2,4,6-trimethylbenzene (392-61-0)

Guidance literature:

With xenon difluoride; hydrogen fluoride; In dichloromethane; at 25 ℃; for 0.333333h;

DOI:10.1021/jo00161a017

Reference yield:

3-fluoro-2,4,6-trimethyl-aniline (444-03-1) → 1,3-difluoro-2,4,6-trimethylbenzene (392-61-0)

Guidance literature:

With hydrogenchloride; sodium tetrafluoroborate; sodium nitrite; Erhitzen des Reaktionsprodukts;

DOI:10.1021/ja01145a055

Reference yield:

2-fluoro-1,3,5-trimethyl-4-nitro-benzene (386-66-3) → 1,3-difluoro-2,4,6-trimethylbenzene (392-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron

2: aqueous hydrochloric acid; sodium nitrite; aqueous sodium fluoroborate solution / Erhitzen des Reaktionsprodukts

With hydrogenchloride; sodium tetrafluoroborate; iron; sodium nitrite;

DOI:10.1021/ja01145a055

upstream raw materials:

3-fluoro-2,4,6-trimethyl-aniline

1,3,5-trimethyl-benzene

2-fluoro-1,3,5-trimethyl-4-nitro-benzene

2,4,6-trimethyl-3-nitro-aniline

Downstream raw materials:

3,5-difluoro-2,4,6-trimethyl-benzoic acid

3,5-difluoro-2,4,6-trimethyl-benzoic acid amide

1,3,5-trifluoro-2,4,6-tris-trichloromethyl-benzene

1,3,5-tris-dichloromethyl-2,4,6-trifluoro-benzene

Refernces

• 1、 Stavber, Stojan,Zupan, Marko. "Effect of Catalyst on the Fluorination of Methyl-Substituted Benzenes with Xenon Difluoride". . p. 2223 - 2226. Retrieved 2007/10/02.