2-Hydroxythiobenzamide

Base Information

• Chemical Name: 2-Hydroxythiobenzamide
• CAS No.: 7133-90-6
• Molecular Formula: C7H7NOS
• Molecular Weight: 153.205
• Hs Code.: 2930909090
• European Community (EC) Number: 674-700-5
• DSSTox Substance ID: DTXSID501306876
• Nikkaji Number: J2.052.682C
• Mol file: 7133-90-6.mol

Synonyms:2-Hydroxythiobenzamide;7133-90-6;2-hydroxybenzene-1-carbothioamide;Thiosalicylamide;2-Hydroxybenzenecarbothioamide;Salicylamide, thio-;2-Hydroxybenzothiamide;2-hydroxybenzothioamide;BRN 2573919;2-Hydroxy-thiobenzamide;C7H7NOS;0-10-00-00134 (Beilstein Handbook Reference);Benzenecarbothioamide, 2-hydroxy-;SCHEMBL2552123;2-Hydroxybenzenecarbothioamide #;(6E)-6-[amino(sulfanyl)methylidene]cyclohexa-2,4-dien-1-one;DTXSID501306876;MFCD01684561;AKOS009345805;FS-1638;LS-144178;CS-0251429;FT-0636360;EN300-54725;A837156;F2167-3930

Chemical Property of 2-Hydroxythiobenzamide

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 119 °C
• Refractive Index: 1.655
• Boiling Point: 300.009 °C at 760 mmHg
• Flash Point: 135.241 °C
• PSA: 78.34000
• Density: 1.339 g/cm³
• LogP: 1.72670
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 153.02483502
• Heavy Atom Count: 10
• Complexity: 138

Purity/Quality:

99%, ^*data from raw suppliers

2-?Hydroxythiobenzamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=S)N)O
• Uses: 2-?Hydroxythiobenzamide is a reagent used in the preparation of thiazole-based chemosensors.

Technology Process of 2-Hydroxythiobenzamide

There total 11 articles about 2-Hydroxythiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 2-hydroxythiobenzamide (7133-90-6)

Guidance literature:

Reference yield: 80.0%

salicylonitrile (611-20-1) → 2-hydroxythiobenzamide (7133-90-6)

Guidance literature:

With O,S-diethyl-dithiophosphoric acid; In water; at 80 ℃; for 6h;

DOI:10.1016/S0040-4020(01)89095-5

Reference yield: 80.0%

salicylonitrile (611-20-1) + O,O-Diethyl hydrogen phosphorodithioate (298-06-6) → 2-hydroxythiobenzamide (7133-90-6)

Guidance literature:

In water; at 80 ℃; for 6h;

upstream raw materials:

salicylamide

salicylonitrile

O,O-Diethyl hydrogen phosphorodithioate

2-(2-Hydroxyphenyl)-1,3-benzoxazin-4-thion

Downstream raw materials:

salicylonitrile

3,5-bis-(2-hydroxy-phenyl)-[1,2,4]dithiazolylium betaine

2-phenyl-2,3-dihydro-benzo[e][1,3]oxazine-4-thione

<2-(2-hydroxyphenyl)-4-thiazolyl>acetic acid ethyl ester

Refernces

• 1、 Kaplan, Anna R.,Musaev, Djamaladdin G.,Wuest, William M.. "Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity". . p. 544 - 551. Retrieved 2021/03/03.
• 2、 Mahata, Alok,Bhaumick, Prabhas,Panday, Anoop Kumar,Yadav, Rahul,Parvin, Tasneem,Choudhury, Lokman H.. "Multicomponent synthesis of diphenyl-1,3-thiazole-barbituric acid hybrids and their fluorescence property studies". . p. 4798 - 4811. Retrieved 2020/04/03.