2,4(1H,3H)-Quinazolinedione, 6-methyl-

Base Information

• Chemical Name: 2,4(1H,3H)-Quinazolinedione, 6-methyl-
• CAS No.: 62484-16-6
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17202
• Hs Code.: 2933990090
• Mol file: 62484-16-6.mol

Synonyms:2,4-Quinazolinediol,6-methyl- (7CI);6-Methyl-1,2,3,4-tetrahydro-2,4-quinazolinedione;6-Methyl-1H-quinazoline-2,4-dione;6-Methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline;6-Methyl-2,4-quinazolinedione;6-Methylquinazoline-2,4(1H,3H)-dione;NSC 338219;

Chemical Property of 2,4(1H,3H)-Quinazolinedione, 6-methyl-

Chemical Property:

• Melting Point: 314-316℃
• Refractive Index: 1.576
• PKA: 11.19±0.20(Predicted)
• PSA: 65.72000
• Density: 1.28 g/cm³
• LogP: 0.52480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methylquinazoline-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4(1H,3H)-Quinazolinedione, 6-methyl-

There total 12 articles about 2,4(1H,3H)-Quinazolinedione, 6-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-5-methylbenzonitrile (5925-93-9) + carbon dioxide (124-38-9,18923-20-1) → 6-methyl-1H-quinazoline-2,4-dione (62484-16-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In dimethyl sulfoxide; at 110 ℃; for 24h; under 15001.5 Torr; Autoclave;

DOI:10.1016/j.tet.2018.04.059

Reference yield: 95.0%

2-Amino-5-methylbenzoic acid (2941-78-8) + urea (57-13-6) → 6-methyl-1H-quinazoline-2,4-dione (62484-16-6)

Guidance literature:

at 150 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.bmc.2021.116351

Reference yield: 91.0%

2-amino-5-methylbenzonitrile (5925-93-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-methyl-1H-quinazoline-2,4-dione (62484-16-6)

Guidance literature:

With zinc(II) chloride; at 200 ℃; for 5h; sealed tube;

DOI:10.1021/ol900093h

upstream raw materials:

6-methyl-3-amino-2,4(1H,3H)-quinazolinedione

potassium cyanate

2-Amino-5-methylbenzoic acid

5-methyl-indole-2,3-dione

Downstream raw materials:

6-methyl-2,4-dichloroquinazoline

N-benzyl-2-chloro-6-methylquinazolin-4-amine

2-chloro-6-methylquinazoline

N-(4-fluorobenzyl)-4-[[(2-(dimethylamino)-6-methylquinazolin-4-yl)amino]methyl]benzamide

Refernces

• 1、 -. "Proton type ionic liquid [HDBN] [2-PyOH] and preparation and application thereof". Paragraph 0021; 0025-0029; 0060-0064. . Retrieved 2021/11/21.
• 2、 -. "N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof". Page/Page column 46-47; 49. . Retrieved 2019/07/03.