1H-Imidazole-4-carboxylic acid, 5-nitro-, methyl ester

Base Information

• Chemical Name: 1H-Imidazole-4-carboxylic acid, 5-nitro-, methyl ester
• CAS No.: 20271-20-9
• Molecular Formula: C₅H₅N₃O₄
• Molecular Weight: 171.112
• Hs Code.: 2933290090
• Mol file: 20271-20-9.mol

Synonyms:5-Imidazolic acid, 4-nitro-, methyl ester;

Chemical Property of 1H-Imidazole-4-carboxylic acid, 5-nitro-, methyl ester

Chemical Property:

• Vapor Pressure: 6.38E-07mmHg at 25°C
• Melting Point: 212-213 °C
• Refractive Index: 1.584
• Boiling Point: 409.7 °C at 760 mmHg
• PKA: 5.99±0.10(Predicted)
• Flash Point: 201.6 °C
• PSA: 100.80000
• Density: 1.545 g/cm³
• LogP: 0.62770
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl5-Nitro-1H-imidazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Imidazole-4-carboxylic acid, 5-nitro-, methyl ester

There total 3 articles about 1H-Imidazole-4-carboxylic acid, 5-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methanol (67-56-1) + imidazole-4-carboxylic acid (1072-84-0) → methyl 5-nitroimidazole-4-carboxylate (20271-20-9)

Guidance literature:

imidazole-4-carboxylic acid; With ammonium nitrate; at 100 ℃; for 48h;

methanol; at 60 ℃; for 24h;

Reference yield:

methanol (67-56-1) → methyl 5-nitroimidazole-4-carboxylate (20271-20-9)

Guidance literature:

With hydrogenchloride;

Reference yield:

methanol (67-56-1) + 5(4)-nitro-1(3)H-imidazole-4(5)-carboxylic acid (40507-59-3) → methyl 5-nitroimidazole-4-carboxylate (20271-20-9)

Guidance literature:

With sulfuric acid;

upstream raw materials:

methanol

5⁽⁴⁾-nitro-1⁽³⁾H-imidazole-4⁽⁵⁾-carboxylic acid

imidazole-4-carboxylic acid

Downstream raw materials:

5-nitro-1(3)H-imidazole-4-carboxylic acid amide

5-nitro-1-β-D-ribofuranosyl-1H-imidazole-4-carboxylic acid amide

4-Nitro-1-β-D-ribofuranosylimidazole-5-carboxamide

methyl 5-amino-1H-imidazole-4-carboxylate

Refernces

• 1、 -. "BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)". Page/Page column 44. . Retrieved 2010/02/12.