Technology Process of Octanal, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-methylene-,
oxime, (4R)-
There total 10 articles about Octanal, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6-methylene-,
oxime, (4R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; sodium acetate;
In
ethanol;
at 20 ℃;
for 1h;
DOI:10.1021/ja0177049
- Guidance literature:
-
Multi-step reaction with 9 steps
1: EtCO2H / 135 °C
2: 247.5 g / KOH / ethanol; H2O / 20 °C
3: Et3N / diethyl ether / 0.67 h / 0 °C
4: 51.0 g / n-BuLi / tetrahydrofuran; various solvent(s) / 1.33 h / -78 - 0 °C
5: 70.4 percent / titanium tetraisopropoxide; i-Pr2NEt; titanium tetrachloride / CH2Cl2 / 9 h / 0 °C
6: 45.85 percent / NaBH4 / tetrahydrofuran; H2O / 12 h / 20 °C
7: 91.5 percent / imidazole / dimethylformamide / 1 h / 20 °C
8: DIBAL / CH2Cl2; toluene / 0.33 h / -78 °C
9: H2NOH*HCl; NaOAc / ethanol / 1 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; titanium tetrachloride; diisobutylaluminium hydride; propionic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
1: Claisen-Johnson rearrangement;
DOI:10.1021/ja0177049
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Et3N / diethyl ether / 0.67 h / 0 °C
2: 51.0 g / n-BuLi / tetrahydrofuran; various solvent(s) / 1.33 h / -78 - 0 °C
3: 70.4 percent / titanium tetraisopropoxide; i-Pr2NEt; titanium tetrachloride / CH2Cl2 / 9 h / 0 °C
4: 45.85 percent / NaBH4 / tetrahydrofuran; H2O / 12 h / 20 °C
5: 91.5 percent / imidazole / dimethylformamide / 1 h / 20 °C
6: DIBAL / CH2Cl2; toluene / 0.33 h / -78 °C
7: H2NOH*HCl; NaOAc / ethanol / 1 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; sodium tetrahydroborate; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja0177049
